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FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.
Csincsi ÁI, Szabó Z, Bánlaki Z, Uzonyi B, Cserhalmi M, Kárpáti É, Tortajada A, Caesar JJE, Prohászka Z, Jokiranta TS, Lea SM, Rodríguez de Córdoba S, Józsi M. Csincsi ÁI, et al. Among authors: tortajada a. J Immunol. 2017 Jul 1;199(1):292-303. doi: 10.4049/jimmunol.1600483. Epub 2017 May 22. J Immunol. 2017. PMID: 28533443 Free article.
Factor H-related proteins determine complement-activating surfaces.
Józsi M, Tortajada A, Uzonyi B, Goicoechea de Jorge E, Rodríguez de Córdoba S. Józsi M, et al. Among authors: tortajada a. Trends Immunol. 2015 Jun;36(6):374-84. doi: 10.1016/j.it.2015.04.008. Epub 2015 May 13. Trends Immunol. 2015. PMID: 25979655 Review.
A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.
Subías M, Tortajada A, Gastoldi S, Galbusera M, López-Perrote A, Lopez Lde J, González-Fernández FA, Villegas-Martínez A, Dominguez M, Llorca O, Noris M, Morgan BP, Rodríguez de Córdoba S. Subías M, et al. Among authors: tortajada a. J Immunol. 2014 Dec 1;193(11):5567-75. doi: 10.4049/jimmunol.1402013. Epub 2014 Oct 29. J Immunol. 2014. PMID: 25355917
Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.
Subías Hidalgo M, Yébenes H, Rodríguez-Gallego C, Martín-Ambrosio A, Domínguez M, Tortajada A, Rodríguez de Córdoba S, Llorca O. Subías Hidalgo M, et al. Among authors: tortajada a. Eur J Immunol. 2017 Mar;47(3):504-515. doi: 10.1002/eji.201646758. Epub 2017 Feb 6. Eur J Immunol. 2017. PMID: 28083930 Free article.
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.
Martínez-Barricarte R, Heurich M, Valdes-Cañedo F, Vazquez-Martul E, Torreira E, Montes T, Tortajada A, Pinto S, Lopez-Trascasa M, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S. Martínez-Barricarte R, et al. Among authors: tortajada a. J Clin Invest. 2010 Oct;120(10):3702-12. doi: 10.1172/JCI43343. Epub 2010 Sep 13. J Clin Invest. 2010. PMID: 20852386 Free PMC article.
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.
Tortajada A, Yébenes H, Abarrategui-Garrido C, Anter J, García-Fernández JM, Martínez-Barricarte R, Alba-Domínguez M, Malik TH, Bedoya R, Cabrera Pérez R, López Trascasa M, Pickering MC, Harris CL, Sánchez-Corral P, Llorca O, Rodríguez de Córdoba S. Tortajada A, et al. J Clin Invest. 2013 Jun;123(6):2434-46. doi: 10.1172/JCI68280. J Clin Invest. 2013. PMID: 23728178 Free PMC article.
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