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Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages.
Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, Leboeuf M, Low D, Oller G, Almeida F, Choy SH, Grisotto M, Renia L, Conway SJ, Stanley ER, Chan JK, Ng LG, Samokhvalov IM, Merad M, Ginhoux F. Hoeffel G, et al. J Exp Med. 2012 Jun 4;209(6):1167-81. doi: 10.1084/jem.20120340. Epub 2012 May 7. J Exp Med. 2012. PMID: 22565823 Free PMC article.