Itoh F - Search Results

1

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Imaeda T, Ono K, Nakai K, Hori Y, Matsukawa J, Takagi T, Fujioka Y, Tarui N, Kondo M, Imanishi A, Inatomi N, Kajino M, Itoh F, Nishida H. Imaeda T, et al. Among authors: itoh f. Bioorg Med Chem. 2017 Jul 15;25(14):3719-3735. doi: 10.1016/j.bmc.2017.05.012. Epub 2017 May 6. Bioorg Med Chem. 2017. PMID: 28522264

2

Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs).

Arikawa Y, Hasuoka A, Nishida H, Hirase K, Inatomi N, Takagi T, Tarui N, Kawamoto M, Imanishi A, Itoh F, Kajino M. Arikawa Y, et al. Among authors: itoh f. Bioorg Med Chem Lett. 2015;25(10):2037-40. doi: 10.1016/j.bmcl.2015.03.094. Epub 2015 Apr 6. Bioorg Med Chem Lett. 2015. PMID: 25891103

3

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Nishida H, Arikawa Y, Hirase K, Imaeda T, Inatomi N, Hori Y, Matsukawa J, Fujioka Y, Hamada T, Iida M, Nishitani M, Imanishi A, Fukui H, Itoh F, Kajino M. Nishida H, et al. Among authors: itoh f. Bioorg Med Chem. 2017 Jul 1;25(13):3298-3314. doi: 10.1016/j.bmc.2017.04.014. Epub 2017 Apr 13. Bioorg Med Chem. 2017. PMID: 28442261

4

Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion.

Nishida H, Fujimori I, Arikawa Y, Hirase K, Ono K, Nakai K, Inatomi N, Hori Y, Matsukawa J, Fujioka Y, Imanishi A, Fukui H, Itoh F. Nishida H, et al. Among authors: itoh f. Bioorg Med Chem. 2017 Jul 1;25(13):3447-3460. doi: 10.1016/j.bmc.2017.04.034. Epub 2017 Apr 27. Bioorg Med Chem. 2017. PMID: 28483454

5

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Asano Y, Kitamura S, Ohra T, Itoh F, Kajino M, Tamura T, Kaneko M, Ikeda S, Igata H, Kawamoto T, Sogabe S, Matsumoto S, Tanaka T, Yamaguchi M, Kimura H, Fukumoto S. Asano Y, et al. Among authors: itoh f. Bioorg Med Chem. 2008 Apr 15;16(8):4699-714. doi: 10.1016/j.bmc.2008.02.028. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18313930

6

Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54.

Kobayashi T, Sasaki S, Tomita N, Fukui S, Kuroda N, Nakayama M, Kiba A, Takatsu Y, Ohtaki T, Itoh F, Baba A. Kobayashi T, et al. Among authors: itoh f. Bioorg Med Chem. 2010 Jun 1;18(11):3841-59. doi: 10.1016/j.bmc.2010.04.036. Epub 2010 Apr 20. Bioorg Med Chem. 2010. PMID: 20457527

7

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Asano Y, Kitamura S, Ohra T, Aso K, Igata H, Tamura T, Kawamoto T, Tanaka T, Sogabe S, Matsumoto S, Yamaguchi M, Kimura H, Itoh F. Asano Y, et al. Among authors: itoh f. Bioorg Med Chem. 2008 Apr 15;16(8):4715-32. doi: 10.1016/j.bmc.2008.02.027. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18313304

8

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

Saitoh M, Kunitomo J, Kimura E, Hayase Y, Kobayashi H, Uchiyama N, Kawamoto T, Tanaka T, Mol CD, Dougan DR, Textor GS, Snell GP, Itoh F. Saitoh M, et al. Among authors: itoh f. Bioorg Med Chem. 2009 Mar 1;17(5):2017-29. doi: 10.1016/j.bmc.2009.01.019. Epub 2009 Jan 15. Bioorg Med Chem. 2009. PMID: 19200745

9

Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors.

Imaeda Y, Miyawaki T, Sakamoto H, Itoh F, Konishi N, Hiroe K, Kawamura M, Tanaka T, Kubo K. Imaeda Y, et al. Among authors: itoh f. Bioorg Med Chem. 2008 Mar 1;16(5):2243-60. doi: 10.1016/j.bmc.2007.11.073. Epub 2007 Dec 3. Bioorg Med Chem. 2008. PMID: 18077174

10

Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH₂ (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.

Nishizawa N, Takatsu Y, Kumano S, Kiba A, Ban J, Tsutsumi S, Matsui H, Matsumoto SI, Yamaguchi M, Ikeda Y, Kusaka M, Ohtaki T, Itoh F, Asami T. Nishizawa N, et al. Among authors: itoh f. J Med Chem. 2016 Oct 13;59(19):8804-8811. doi: 10.1021/acs.jmedchem.6b00379. Epub 2016 Sep 21. J Med Chem. 2016. PMID: 27589480

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