Janetka JW - Search Results

1

Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease.

Mydock-McGrane LK, Hannan TJ, Janetka JW. Mydock-McGrane LK, et al. Among authors: janetka jw. Expert Opin Drug Discov. 2017 Jul;12(7):711-731. doi: 10.1080/17460441.2017.1331216. Epub 2017 Jun 2. Expert Opin Drug Discov. 2017. PMID: 28506090 Free PMC article. Review.

2

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19.

Boon ACM, L Bricker T, Fritch EJ, Leist SR, Gully K, Baric RS, Graham RL, Troan BV, Mahoney M, Janetka JW. Boon ACM, et al. Among authors: janetka jw. bioRxiv [Preprint]. 2024 Feb 12:2024.02.09.579701. doi: 10.1101/2024.02.09.579701. bioRxiv. 2024. Update in: J Virol. 2024 May 14;98(5):e0190323. doi: 10.1128/jvi.01903-23 PMID: 38405752 Free PMC article. Updated. Preprint.

3

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW. Han Z, et al. Among authors: janetka jw. J Med Chem. 2010 Jun 24;53(12):4779-92. doi: 10.1021/jm100438s. J Med Chem. 2010. PMID: 20507142 Free PMC article.

4

Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ. Cusumano CK, et al. Among authors: janetka jw. Sci Transl Med. 2011 Nov 16;3(109):109ra115. doi: 10.1126/scitranslmed.3003021. Sci Transl Med. 2011. PMID: 22089451 Free PMC article.

5

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW. Han Z, et al. Among authors: janetka jw. J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13. J Med Chem. 2012. PMID: 22449031 Free PMC article.

6

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Kostakioti M, Hadjifrangiskou M, Cusumano CK, Hannan TJ, Janetka JW, Hultgren SJ. Kostakioti M, et al. Among authors: janetka jw. Infect Immun. 2012 Aug;80(8):2826-34. doi: 10.1128/IAI.00283-12. Epub 2012 Jun 4. Infect Immun. 2012. PMID: 22665375 Free PMC article.

7

Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. Guiton PS, et al. Among authors: janetka jw. Antimicrob Agents Chemother. 2012 Sep;56(9):4738-45. doi: 10.1128/AAC.00447-12. Epub 2012 Jun 25. Antimicrob Agents Chemother. 2012. PMID: 22733070 Free PMC article.

8

A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131.

Totsika M, Kostakioti M, Hannan TJ, Upton M, Beatson SA, Janetka JW, Hultgren SJ, Schembri MA. Totsika M, et al. Among authors: janetka jw. J Infect Dis. 2013 Sep;208(6):921-8. doi: 10.1093/infdis/jit245. Epub 2013 Jun 3. J Infect Dis. 2013. PMID: 23737602 Free PMC article.

9

Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli.

Greene SE, Hibbing ME, Janetka J, Chen SL, Hultgren SJ. Greene SE, et al. mBio. 2015 Jun 30;6(4):e00820. doi: 10.1128/mBio.00820-15. mBio. 2015. PMID: 26126855 Free PMC article.

10

Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.

Mydock-McGrane LK, Cusumano ZT, Janetka JW. Mydock-McGrane LK, et al. Among authors: janetka jw. Expert Opin Ther Pat. 2016;26(2):175-97. doi: 10.1517/13543776.2016.1131266. Epub 2016 Jan 22. Expert Opin Ther Pat. 2016. PMID: 26651364 Review.

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