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Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor.
Chan S, Frasch A, Mandava CS, Ch'ng JH, Quintana MDP, Vesterlund M, Ghorbal M, Joannin N, Franzén O, Lopez-Rubio JJ, Barbieri S, Lanzavecchia A, Sanyal S, Wahlgren M. Chan S, et al. Among authors: lanzavecchia a. Nat Microbiol. 2017 May 8;2:17068. doi: 10.1038/nmicrobiol.2017.68. Nat Microbiol. 2017. PMID: 28481333
Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA.
Barfod L, Bernasconi NL, Dahlbäck M, Jarrossay D, Andersen PH, Salanti A, Ofori MF, Turner L, Resende M, Nielsen MA, Theander TG, Sallusto F, Lanzavecchia A, Hviid L. Barfod L, et al. Among authors: lanzavecchia a. Mol Microbiol. 2007 Jan;63(2):335-47. doi: 10.1111/j.1365-2958.2006.05503.x. Epub 2006 Dec 14. Mol Microbiol. 2007. PMID: 17176260 Free PMC article.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan J, Pieper K, Piccoli L, Abdi A, Perez MF, Geiger R, Tully CM, Jarrossay D, Maina Ndungu F, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A. Tan J, et al. Among authors: lanzavecchia a. Nature. 2016 Jan 7;529(7584):105-109. doi: 10.1038/nature16450. Epub 2015 Dec 23. Nature. 2016. PMID: 26700814 Free PMC article.
High-avidity IgA protects the intestine by enchaining growing bacteria.
Moor K, Diard M, Sellin ME, Felmy B, Wotzka SY, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co AD, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regoes RR, Loverdo C, Stocker R, Brumley DR, Hardt WD, Slack E. Moor K, et al. Among authors: lanzavecchia a. Nature. 2017 Apr 27;544(7651):498-502. doi: 10.1038/nature22058. Epub 2017 Apr 12. Nature. 2017. PMID: 28405025
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper K, Tan J, Piccoli L, Foglierini M, Barbieri S, Chen Y, Silacci-Fregni C, Wolf T, Jarrossay D, Anderle M, Abdi A, Ndungu FM, Doumbo OK, Traore B, Tran TM, Jongo S, Zenklusen I, Crompton PD, Daubenberger C, Bull PC, Sallusto F, Lanzavecchia A. Pieper K, et al. Among authors: lanzavecchia a. Nature. 2017 Aug 31;548(7669):597-601. doi: 10.1038/nature23670. Epub 2017 Aug 23. Nature. 2017. PMID: 28847005 Free PMC article.
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Tan J, Sack BK, Oyen D, Zenklusen I, Piccoli L, Barbieri S, Foglierini M, Fregni CS, Marcandalli J, Jongo S, Abdulla S, Perez L, Corradin G, Varani L, Sallusto F, Sim BKL, Hoffman SL, Kappe SHI, Daubenberger C, Wilson IA, Lanzavecchia A. Tan J, et al. Among authors: lanzavecchia a. Nat Med. 2018 May;24(4):401-407. doi: 10.1038/nm.4513. Epub 2018 Mar 19. Nat Med. 2018. PMID: 29554084 Free PMC article.
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton PD, Geiger R, Sallusto F, Kwong PD, Lanzavecchia A. Chen Y, et al. Among authors: lanzavecchia a. Nature. 2021 Apr;592(7855):639-643. doi: 10.1038/s41586-021-03378-6. Epub 2021 Mar 31. Nature. 2021. PMID: 33790470 Free PMC article.
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD. Xu K, et al. Among authors: lanzavecchia a. Nat Commun. 2021 Jul 9;12(1):4226. doi: 10.1038/s41467-021-24291-6. Nat Commun. 2021. PMID: 34244481 Free PMC article.
397 results