Giancotti FG - Search Results

1

Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.

Cooper J, Xu Q, Zhou L, Pavlovic M, Ojeda V, Moulick K, de Stanchina E, Poirier JT, Zauderer M, Rudin CM, Karajannis MA, Hanemann CO, Giancotti FG. Cooper J, et al. Among authors: giancotti fg. Mol Cancer Ther. 2017 Aug;16(8):1693-1704. doi: 10.1158/1535-7163.MCT-16-0821. Epub 2017 May 3. Mol Cancer Ther. 2017. PMID: 28468780 Free PMC article.

2

Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling.

López-Lago MA, Okada T, Murillo MM, Socci N, Giancotti FG. López-Lago MA, et al. Among authors: giancotti fg. Mol Cell Biol. 2009 Aug;29(15):4235-49. doi: 10.1128/MCB.01578-08. Epub 2009 May 18. Mol Cell Biol. 2009. PMID: 19451229 Free PMC article.

3

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.

Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Li W, et al. Among authors: giancotti fg. Cell. 2010 Feb 19;140(4):477-90. doi: 10.1016/j.cell.2010.01.029. Cell. 2010. PMID: 20178741 Free PMC article.

4

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.

Ammoun S, Cunliffe CH, Allen JC, Chiriboga L, Giancotti FG, Zagzag D, Hanemann CO, Karajannis MA. Ammoun S, et al. Among authors: giancotti fg. Neuro Oncol. 2010 Aug;12(8):834-43. doi: 10.1093/neuonc/noq012. Epub 2010 Feb 11. Neuro Oncol. 2010. PMID: 20511180 Free PMC article.

5

Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.

Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P. Rossi F, et al. Among authors: giancotti fg. Mol Cancer Res. 2010 Sep;8(9):1271-83. doi: 10.1158/1541-7786.MCR-10-0065. Epub 2010 Aug 24. Mol Cancer Res. 2010. PMID: 20736294 Free PMC article.

6

Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1).

Li W, Giancotti FG. Li W, et al. Among authors: giancotti fg. Cell Cycle. 2010 Nov 15;9(22):4433-6. doi: 10.4161/cc.9.22.13838. Epub 2010 Nov 15. Cell Cycle. 2010. PMID: 21084862 Free PMC article.

7

Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.

Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Cooper J, et al. Among authors: giancotti fg. Sci Signal. 2011 Aug 23;4(188):pt6. doi: 10.1126/scisignal.2002314. Sci Signal. 2011. PMID: 21878678

8

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

Li W, Cooper J, Karajannis MA, Giancotti FG. Li W, et al. Among authors: giancotti fg. EMBO Rep. 2012 Mar;13(3):204-15. doi: 10.1038/embor.2012.11. EMBO Rep. 2012. PMID: 22482125 Free PMC article. Review.

9

New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment.

Ladanyi M, Zauderer MG, Krug LM, Ito T, McMillan R, Bott M, Giancotti F. Ladanyi M, et al. Clin Cancer Res. 2012 Sep 1;18(17):4485-90. doi: 10.1158/1078-0432.CCR-11-2375. Epub 2012 Jul 23. Clin Cancer Res. 2012. PMID: 22825583 Free PMC article.

10

β4 Integrin signaling induces expansion of prostate tumor progenitors.

Yoshioka T, Otero J, Chen Y, Kim YM, Koutcher JA, Satagopan J, Reuter V, Carver B, de Stanchina E, Enomoto K, Greenberg NM, Scardino PT, Scher HI, Sawyers CL, Giancotti FG. Yoshioka T, et al. Among authors: giancotti fg. J Clin Invest. 2013 Feb;123(2):682-99. doi: 10.1172/JCI60720. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348745 Free PMC article.

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