Bruno JJ - Search Results

1

Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856).

Venuti MC, Alvarez R, Bruno JJ, Strosberg AM, Gu L, Chiang HS, Massey IJ, Chu N, Fried JH. Venuti MC, et al. Among authors: bruno jj. J Med Chem. 1988 Nov;31(11):2145-52. doi: 10.1021/jm00119a015. J Med Chem. 1988. PMID: 2846840

2

Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.

Venuti MC, Stephenson RA, Alvarez R, Bruno JJ, Strosberg AM. Venuti MC, et al. Among authors: bruno jj. J Med Chem. 1988 Nov;31(11):2136-45. doi: 10.1021/jm00119a014. J Med Chem. 1988. PMID: 2846839

3

Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide.

Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A. Jones GH, et al. Among authors: bruno jj. J Med Chem. 1987 Feb;30(2):295-303. doi: 10.1021/jm00385a011. J Med Chem. 1987. PMID: 3027338

4

Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).

Venuti MC, Jones GH, Alvarez R, Bruno JJ. Venuti MC, et al. Among authors: bruno jj. J Med Chem. 1987 Feb;30(2):303-18. doi: 10.1021/jm00385a012. J Med Chem. 1987. PMID: 3027339

5

A potent and selective inhibitor of cyclic AMP phosphodiesterase with potential cardiotonic and antithrombotic properties.

Alvarez R, Banerjee GL, Bruno JJ, Jones GL, Littschwager K, Strosberg AM, Venuti MC. Alvarez R, et al. Among authors: bruno jj. Mol Pharmacol. 1986 Jun;29(6):554-60. Mol Pharmacol. 1986. PMID: 3012320

6

Effects of enprostil on cardiovascular and respiratory parameters in the dog, and on hematologic parameters in the rat, monkey, and human.

Johnson LG, Bruno JJ, Allely MC, Eglen RM, Chang K, Yang D, Alps BJ, Rosenkranz RP, Strosberg AM. Johnson LG, et al. Among authors: bruno jj. Arzneimittelforschung. 1989 Nov;39(11):1443-8. Arzneimittelforschung. 1989. PMID: 2515862

7

RS-82856, a selective phosphodiesterase inhibitor with inotropic, afterload reduction and antithrombotic properties.

Strosberg AM, Johnson L, Montgomery W, Lee CH, Alvarez R, Bruno JJ, Jones GH, Venuti MC. Strosberg AM, et al. Among authors: bruno jj. Proc West Pharmacol Soc. 1987;30:5-10. Proc West Pharmacol Soc. 1987. PMID: 3628319 No abstract available.

8

3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase.

Martinez GR, Walker KA, Hirschfeld DR, Bruno JJ, Yang DS, Maloney PJ. Martinez GR, et al. Among authors: bruno jj. J Med Chem. 1992 Feb 21;35(4):620-8. doi: 10.1021/jm00082a002. J Med Chem. 1992. PMID: 1311763

9

Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin.

Alvarez R, Eglen RM, Chang LF, Bruno JJ, Artis DR, Kluge AF, Whiting RL. Alvarez R, et al. Among authors: bruno jj. Prostaglandins. 1991 Aug;42(2):105-19. doi: 10.1016/0090-6980(91)90070-v. Prostaglandins. 1991. PMID: 1775633

10

Activation of cardiac adenylate cyclase: horminal modification of the magnesium ion requirement.

Alvarez R, Bruno JJ. Alvarez R, et al. Among authors: bruno jj. Proc Natl Acad Sci U S A. 1977 Jan;74(1):92-5. doi: 10.1073/pnas.74.1.92. Proc Natl Acad Sci U S A. 1977. PMID: 264697 Free PMC article.

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