Johnson KM - Search Results

1

Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine.

Sarkar U, Hillebrand R, Johnson KM, Cummings AH, Phung NL, Rajapakse A, Zhou H, Willis JR, Barnes CL, Gates KS. Sarkar U, et al. Among authors: johnson km. J Heterocycl Chem. 2017 Jan;54(1):155-160. doi: 10.1002/jhet.2559. Epub 2015 Nov 25. J Heterocycl Chem. 2017. PMID: 28439141 Free PMC article.

2

On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA.

Johnson KM, Price NE, Wang J, Fekry MI, Dutta S, Seiner DR, Wang Y, Gates KS. Johnson KM, et al. J Am Chem Soc. 2013 Jan 23;135(3):1015-25. doi: 10.1021/ja308119q. Epub 2013 Jan 11. J Am Chem Soc. 2013. PMID: 23215239 Free PMC article.

3

Interstrand DNA-DNA cross-link formation between adenine residues and abasic sites in duplex DNA.

Price NE, Johnson KM, Wang J, Fekry MI, Wang Y, Gates KS. Price NE, et al. Among authors: johnson km. J Am Chem Soc. 2014 Mar 5;136(9):3483-90. doi: 10.1021/ja410969x. Epub 2014 Feb 20. J Am Chem Soc. 2014. PMID: 24506784 Free PMC article.

4

Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

Johnson KM, Parsons ZD, Barnes CL, Gates KS. Johnson KM, et al. J Org Chem. 2014 Aug 15;79(16):7520-31. doi: 10.1021/jo501252p. Epub 2014 Jul 25. J Org Chem. 2014. PMID: 25029663 Free PMC article.

5

Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNA.

Catalano MJ, Liu S, Andersen N, Yang Z, Johnson KM, Price NE, Wang Y, Gates KS. Catalano MJ, et al. Among authors: johnson km. J Am Chem Soc. 2015 Mar 25;137(11):3933-45. doi: 10.1021/jacs.5b00669. Epub 2015 Mar 11. J Am Chem Soc. 2015. PMID: 25710271 Free PMC article.

6

Characterization of Interstrand DNA-DNA Cross-Links Derived from Abasic Sites Using Bacteriophage ϕ29 DNA Polymerase.

Yang Z, Price NE, Johnson KM, Gates KS. Yang Z, et al. Among authors: johnson km. Biochemistry. 2015 Jul 14;54(27):4259-66. doi: 10.1021/acs.biochem.5b00482. Epub 2015 Jul 2. Biochemistry. 2015. PMID: 26103998 Free PMC article.

7

A New Cross-Link for an Old Cross-Linking Drug: The Nitrogen Mustard Anticancer Agent Mechlorethamine Generates Cross-Links Derived from Abasic Sites in Addition to the Expected Drug-Bridged Cross-Links.

Nejad MI, Johnson KM, Price NE, Gates KS. Nejad MI, et al. Among authors: johnson km. Biochemistry. 2016 Dec 20;55(50):7033-7041. doi: 10.1021/acs.biochem.6b01080. Epub 2016 Dec 8. Biochemistry. 2016. PMID: 27992994

8

Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA.

Yang Z, Price NE, Johnson KM, Wang Y, Gates KS. Yang Z, et al. Among authors: johnson km. Nucleic Acids Res. 2017 Jun 20;45(11):6275-6283. doi: 10.1093/nar/gkx394. Nucleic Acids Res. 2017. PMID: 28531327 Free PMC article.

9

Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.

Shen X, Laber CH, Sarkar U, Galazzi F, Johnson KM, Mahieu NG, Hillebrand R, Fuchs-Knotts T, Barnes CL, Baker GA, Gates KS. Shen X, et al. Among authors: johnson km. J Org Chem. 2018 Mar 16;83(6):3126-3131. doi: 10.1021/acs.joc.7b03035. Epub 2018 Feb 26. J Org Chem. 2018. PMID: 29461834

10

Interstrand Cross-Link Formation Involving Reaction of a Mispaired Cytosine Residue with an Abasic Site in Duplex DNA.

Varela JG, Pierce LE, Guo X, Price NE, Johnson KM, Yang Z, Wang Y, Gates KS. Varela JG, et al. Among authors: johnson km. Chem Res Toxicol. 2021 Apr 19;34(4):1124-1132. doi: 10.1021/acs.chemrestox.1c00004. Epub 2021 Mar 30. Chem Res Toxicol. 2021. PMID: 33784065 Free PMC article.

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