Ahuja LG - Search Results

1

A dynamic hydrophobic core orchestrates allostery in protein kinases.

Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. Kim J, et al. Among authors: ahuja lg. Sci Adv. 2017 Apr 7;3(4):e1600663. doi: 10.1126/sciadv.1600663. eCollection 2017 Apr. Sci Adv. 2017. PMID: 28435869 Free PMC article.

2

Kinase regulation by hydrophobic spine assembly in cancer.

Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Hu J, et al. Among authors: ahuja lg. Mol Cell Biol. 2015 Jan;35(1):264-76. doi: 10.1128/MCB.00943-14. Epub 2014 Oct 27. Mol Cell Biol. 2015. PMID: 25348715 Free PMC article.

3

Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases.

Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. Meharena HS, et al. Among authors: ahuja lg. PLoS Biol. 2016 Nov 30;14(11):e2000127. doi: 10.1371/journal.pbio.2000127. eCollection 2016 Nov. PLoS Biol. 2016. PMID: 27902690 Free PMC article.

4

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.

Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. Ahuja LG, et al. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E931-E940. doi: 10.1073/pnas.1620667114. Epub 2017 Jan 23. Proc Natl Acad Sci U S A. 2017. PMID: 28115705 Free PMC article.

5

Tuning the "violin" of protein kinases: The role of dynamics-based allostery.

Ahuja LG, Taylor SS, Kornev AP. Ahuja LG, et al. IUBMB Life. 2019 Jun;71(6):685-696. doi: 10.1002/iub.2057. Epub 2019 May 7. IUBMB Life. 2019. PMID: 31063633 Free PMC article. Review.

6

A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.

Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. Meng Y, et al. Among authors: ahuja lg. J Mol Biol. 2018 Mar 16;430(6):881-889. doi: 10.1016/j.jmb.2018.01.019. Epub 2018 Feb 2. J Mol Biol. 2018. PMID: 29410316 Free PMC article.

7

Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. Wang Y, et al. Among authors: ahuja lg. Nat Commun. 2019 Feb 18;10(1):799. doi: 10.1038/s41467-019-08655-7. Nat Commun. 2019. PMID: 30778078 Free PMC article.

8

Dynamic allostery-based molecular workings of kinase:peptide complexes.

Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. Ahuja LG, et al. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15052-15061. doi: 10.1073/pnas.1900163116. Epub 2019 Jul 8. Proc Natl Acad Sci U S A. 2019. PMID: 31285328 Free PMC article.

9

Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.

Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. Lu TW, et al. Among authors: ahuja lg. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16347-16356. doi: 10.1073/pnas.1906036116. Epub 2019 Jul 30. Proc Natl Acad Sci U S A. 2019. PMID: 31363049 Free PMC article.

10

Kinases and pseudokinases: lessons from RAF.

Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Shaw AS, et al. Among authors: ahuja lg. Mol Cell Biol. 2014 May;34(9):1538-46. doi: 10.1128/MCB.00057-14. Epub 2014 Feb 24. Mol Cell Biol. 2014. PMID: 24567368 Free PMC article. Review.

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