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Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer.
Rai A, Kumar U, Raj V, Singh AK, Kumar P, Keshari AK, Kumar D, Maity B, De A, Samanta A, Nath S, Prakash A, Gosipatala SB, Chand G, Saha S. Rai A, et al. Among authors: singh ak. Pharmacol Res. 2018 Jun;132:188-203. doi: 10.1016/j.phrs.2017.12.010. Epub 2017 Dec 8. Pharmacol Res. 2018. PMID: 29229353
6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals.
Mishra P, Raj V, Bhadauria AS, Singh AK, Rai A, Kumar P, Keshari AK, De A, Samanta A, Kumar U, Kumar D, Maity B, Nath S, Prakash A, Ansari KM, Saha S. Mishra P, et al. Among authors: singh ak. Biomed Pharmacother. 2018 Apr;100:282-295. doi: 10.1016/j.biopha.2018.02.009. Epub 2018 Feb 16. Biomed Pharmacother. 2018. PMID: 29448205
p-TSA-promoted syntheses of 5H-benzo[h] thiazolo[2,3-b]quinazoline and indeno[1,2-d] thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma.
Keshari AK, Singh AK, Raj V, Rai A, Trivedi P, Ghosh B, Kumar U, Rawat A, Kumar D, Saha S. Keshari AK, et al. Among authors: singh ak. Drug Des Devel Ther. 2017 May 29;11:1623-1642. doi: 10.2147/DDDT.S136692. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 28615927 Free PMC article.
5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction.
Keshari AK, Singh AK, Kumar U, Raj V, Rai A, Kumar P, Kumar D, Maity B, Nath S, Prakash A, Saha S. Keshari AK, et al. Among authors: singh ak. Drug Des Devel Ther. 2017 Oct 13;11:2981-2995. doi: 10.2147/DDDT.S143075. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 29075102 Free PMC article.
5,928 results