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Cisplatin Analogs Confer Protection against Cyanide Poisoning.
Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Nath AK, et al. Among authors: brenner m. Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13. Cell Chem Biol. 2017. PMID: 28416275 Free PMC article.
Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.
Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK. Morningstar J, et al. Among authors: brenner m. FASEB Bioadv. 2019 Feb;1(2):81-92. doi: 10.1096/fba.1024. Epub 2018 Oct 8. FASEB Bioadv. 2019. PMID: 31355359 Free PMC article.
A countermeasure development pipeline.
MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. MacRae CA, et al. Among authors: brenner m. Ann N Y Acad Sci. 2016 Aug;1378(1):58-67. doi: 10.1111/nyas.13224. Ann N Y Acad Sci. 2016. PMID: 27737495 Free PMC article. Review.
Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.
Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Sips PY, et al. Among authors: brenner m. PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018. PLoS One. 2018. PMID: 29879736 Free PMC article.
Glyoxylate protects against cyanide toxicity through metabolic modulation.
Nielson JR, Nath AK, Doane KP, Shi X, Lee J, Tippetts EG, Saha K, Morningstar J, Hicks KG, Chan A, Zhao Y, Kelly A, Hendry-Hofer TB, Witeof A, Sips PY, Mahon S, Bebarta VS, Davisson VJ, Boss GR, Rutter J, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Nielson JR, et al. Among authors: brenner m. Sci Rep. 2022 Mar 23;12(1):4982. doi: 10.1038/s41598-022-08803-y. Sci Rep. 2022. PMID: 35322094 Free PMC article.
2,264 results