Frech M - Search Results

1

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, IJzerman AP, Müller-Fahrnow A, Ecker GF. Schuetz DA, et al. Among authors: frech m. Drug Discov Today. 2017 Jun;22(6):896-911. doi: 10.1016/j.drudis.2017.02.002. Epub 2017 Apr 13. Drug Discov Today. 2017. PMID: 28412474 Review.

2

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding.

Amaral M, Kokh DB, Bomke J, Wegener A, Buchstaller HP, Eggenweiler HM, Matias P, Sirrenberg C, Wade RC, Frech M. Amaral M, et al. Among authors: frech m. Nat Commun. 2017 Dec 22;8(1):2276. doi: 10.1038/s41467-017-02258-w. Nat Commun. 2017. PMID: 29273709 Free PMC article.

3

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

Schuetz DA, Richter L, Amaral M, Grandits M, Grädler U, Musil D, Buchstaller HP, Eggenweiler HM, Frech M, Ecker GF. Schuetz DA, et al. Among authors: frech m. J Med Chem. 2018 May 24;61(10):4397-4411. doi: 10.1021/acs.jmedchem.8b00080. Epub 2018 May 10. J Med Chem. 2018. PMID: 29701469

4

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.

Kokh DB, Amaral M, Bomke J, Grädler U, Musil D, Buchstaller HP, Dreyer MK, Frech M, Lowinski M, Vallee F, Bianciotto M, Rak A, Wade RC. Kokh DB, et al. Among authors: frech m. J Chem Theory Comput. 2018 Jul 10;14(7):3859-3869. doi: 10.1021/acs.jctc.8b00230. Epub 2018 Jun 4. J Chem Theory Comput. 2018. PMID: 29768913 Free article.

5

Ligand-Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free-Towards a Conformational Activity Screening for Drug Discovery.

Güldenhaupt J, Amaral M, Kötting C, Schartner J, Musil D, Frech M, Gerwert K. Güldenhaupt J, et al. Among authors: frech m. Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9955-9960. doi: 10.1002/anie.201802603. Epub 2018 Jul 3. Angew Chem Int Ed Engl. 2018. PMID: 29772085 Free PMC article.

6

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC, Knapp S. Berger BT, et al. Among authors: frech m. Cell Chem Biol. 2021 May 20;28(5):686-698.e7. doi: 10.1016/j.chembiol.2021.01.003. Epub 2021 Jan 25. Cell Chem Biol. 2021. PMID: 33497606 Free article.

7

Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations.

Wolf S, Amaral M, Lowinski M, Vallée F, Musil D, Güldenhaupt J, Dreyer MK, Bomke J, Frech M, Schlitter J, Gerwert K. Wolf S, et al. Among authors: frech m. J Chem Inf Model. 2019 Dec 23;59(12):5135-5147. doi: 10.1021/acs.jcim.9b00592. Epub 2019 Nov 22. J Chem Inf Model. 2019. PMID: 31697501

8

Structural and biophysical characterization of the Syk activation switch.

Grädler U, Schwarz D, Dresing V, Musil D, Bomke J, Frech M, Greiner H, Jäkel S, Rysiok T, Müller-Pompalla D, Wegener A. Grädler U, et al. Among authors: frech m. J Mol Biol. 2013 Jan 23;425(2):309-33. doi: 10.1016/j.jmb.2012.11.007. Epub 2012 Nov 12. J Mol Biol. 2013. PMID: 23154170

9

Structure of the leech protein saratin and characterization of its binding to collagen.

Gronwald W, Bomke J, Maurer T, Domogalla B, Huber F, Schumann F, Kremer W, Fink F, Rysiok T, Frech M, Kalbitzer HR. Gronwald W, et al. Among authors: frech m. J Mol Biol. 2008 Sep 12;381(4):913-27. doi: 10.1016/j.jmb.2008.06.034. Epub 2008 Jun 18. J Mol Biol. 2008. PMID: 18585393

10

Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process.

Leykauf K, Salek M, Bomke J, Frech M, Lehmann WD, Dürst M, Alonso A. Leykauf K, et al. Among authors: frech m. J Cell Sci. 2006 Sep 1;119(Pt 17):3634-42. doi: 10.1242/jcs.03149. J Cell Sci. 2006. PMID: 16931598

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