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Page 1
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
Bouché L, Christ CD, Siegel S, Fernández-Montalván AE, Holton SJ, Fedorov O, Ter Laak A, Sugawara T, Stöckigt D, Tallant C, Bennett J, Monteiro O, Díaz-Sáez L, Siejka P, Meier J, Pütter V, Weiske J, Müller S, Huber KVM, Hartung IV, Haendler B. Bouché L, et al. J Med Chem. 2017 May 11;60(9):4002-4022. doi: 10.1021/acs.jmedchem.7b00306. Epub 2017 May 1. J Med Chem. 2017. PMID: 28402630 Free PMC article.
Concentration Dependence of the Unbound Partition Coefficient Kpuu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.
Trünkle C, Lechner C, Korr D, Bouché L, Barak N, Fernández-Montalván A, Süssmuth RD, Reichel A. Trünkle C, et al. Among authors: bouche l. Drug Metab Dispos. 2020 Jul;48(7):553-562. doi: 10.1124/dmd.120.090563. Epub 2020 May 1. Drug Metab Dispos. 2020. PMID: 32357973
Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
Sutherland M, Li A, Kaghad A, Panagopoulos D, Li F, Szewczyk M, Smil D, Scholten C, Bouché L, Stellfeld T, Arrowsmith CH, Barsyte D, Vedadi M, Hartung IV, Steuber H, Britton R, Santhakumar V. Sutherland M, et al. Among authors: bouche l. ChemMedChem. 2021 Apr 8;16(7):1116-1125. doi: 10.1002/cmdc.202100018. Epub 2021 Mar 4. ChemMedChem. 2021. PMID: 33513288
BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe.
Günther J, Hillig RC, Zimmermann K, Kaulfuss S, Lemos C, Nguyen D, Rehwinkel H, Habgood M, Lechner C, Neuhaus R, Ganzer U, Drewes M, Chai J, Bouché L. Günther J, et al. Among authors: bouche l. J Med Chem. 2022 Nov 10;65(21):14366-14390. doi: 10.1021/acs.jmedchem.2c00441. Epub 2022 Oct 19. J Med Chem. 2022. PMID: 36261130 Free PMC article.
[Nurse practitioner: experience of implementation in primary care].
Levasseur I, Bouche L, Grandchamp C, Staeger P, Grasset N. Levasseur I, et al. Among authors: bouche l. Rev Med Suisse. 2024 Dec 11;20(898-2):2339-2342. doi: 10.53738/REVMED.2024.20.898-2.2339. Rev Med Suisse. 2024. PMID: 39663969 French.
Novel Macrocyclic NLRP3 Inhibitors.
Mesch S, Shannon J, Miller D, MacLeod A, Bouché L, Johnston HJ, Matthews K, Paehler A, Best S, Guba W, Alanine T, Halai R, Charge L, Garside S, Thom S, Incerti-Pradillos C, McPherson C, Carrillo J, St-Gallay S, Rigo P, Schlicht S, Hendrick AG, Lerner C, Piali L, Blaising J, Mracsko EZ, Jaeschke G, Cooper MA. Mesch S, et al. Among authors: bouche l. J Med Chem. 2024 Dec 12;67(23):20911-20932. doi: 10.1021/acs.jmedchem.4c01376. Epub 2024 Nov 25. J Med Chem. 2024. PMID: 39585325
Discovery and Characterization of BAY-184: A New Potent and Selective Acylsulfonamide-Benzofuran In Vivo-Active KAT6AB Inhibitor.
Ter Laak A, Hillig RC, Ferrara SJ, Korr D, Barak N, Lienau P, Herbert S, Fernández-Montalván AE, Neuhaus R, Gorjánácz M, Puetter V, Badock V, Bone W, Strathdee C, Siegel F, Schatz C, Nowak-Reppel K, Doehr O, Gradl S, Hartung IV, Meyerson M, Bouché L. Ter Laak A, et al. Among authors: bouche l. J Med Chem. 2024 Nov 14;67(21):19282-19303. doi: 10.1021/acs.jmedchem.4c01709. Epub 2024 Oct 25. J Med Chem. 2024. PMID: 39450890 Free PMC article.
Decreased fucosylation impacts epithelial integrity and increases risk for COPD.
Swaby C, Yeung-Luk B, Thapa S, Nishida K, Wally A, Ghosh B, Niederkofler A, Luk S, Girgis M, Keller A, Cortez C, Ramaswamy S, Wilmsen K, Bouché L, Dell A, Drummond MB, Putcha N, Haslam SM, Mathias R, Hansel NN, Sheng J, Sidhaye V. Swaby C, et al. Among authors: bouche l. bioRxiv [Preprint]. 2023 Nov 2:2023.10.31.564805. doi: 10.1101/2023.10.31.564805. bioRxiv. 2023. PMID: 37961411 Free PMC article. Preprint.
24 results