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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression.
Pesch AM, Chandler BC, Michmerhuizen AR, Carter HM, Hirsh NH, Wilder-Romans K, Liu M, Ward T, Ritter CL, Nino CA, Jungles KM, Pierce LJ, Rae JM, Speers CW. Pesch AM, et al. Among authors: hirsh nh. Cancer Res Commun. 2022 Jul;2(7):679-693. doi: 10.1158/2767-9764.crc-22-0024. Epub 2022 Jul 20. Cancer Res Commun. 2022. PMID: 36381235 Free PMC article.
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε.
Sviderskiy VO, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, Tonzi P, Mir H, Neel BG, Huang TT, Adams S, Ruggles KV, Possemato R. Sviderskiy VO, et al. Among authors: hirsh n. Mol Cell. 2020 Nov 19;80(4):682-698.e7. doi: 10.1016/j.molcel.2020.10.016. Epub 2020 Nov 4. Mol Cell. 2020. PMID: 33152268 Free PMC article.
Short-term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor-Positive Breast Cancers.
Pesch AM, Hirsh NH, Chandler BC, Michmerhuizen AR, Ritter CL, Androsiglio MP, Wilder-Romans K, Liu M, Gersch CL, Larios JM, Pierce LJ, Rae JM, Speers CW. Pesch AM, et al. Among authors: hirsh nh. Clin Cancer Res. 2020 Dec 15;26(24):6568-6580. doi: 10.1158/1078-0432.CCR-20-2269. Epub 2020 Sep 23. Clin Cancer Res. 2020. PMID: 32967938 Free PMC article.
TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination.
Chandler BC, Moubadder L, Ritter CL, Liu M, Cameron M, Wilder-Romans K, Zhang A, Pesch AM, Michmerhuizen AR, Hirsh N, Androsiglio M, Ward T, Olsen E, Niknafs YS, Merajver S, Thomas DG, Brown PH, Lawrence TS, Nyati S, Pierce LJ, Chinnaiyan A, Speers C. Chandler BC, et al. Among authors: hirsh n. J Clin Invest. 2020 Feb 3;130(2):958-973. doi: 10.1172/JCI130435. J Clin Invest. 2020. PMID: 31961339 Free PMC article.
PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation.
Michmerhuizen AR, Pesch AM, Moubadder L, Chandler BC, Wilder-Romans K, Cameron M, Olsen E, Thomas DG, Zhang A, Hirsh N, Ritter CL, Liu M, Nyati S, Pierce LJ, Jagsi R, Speers C. Michmerhuizen AR, et al. Among authors: hirsh n. Mol Cancer Ther. 2019 Nov;18(11):2063-2073. doi: 10.1158/1535-7163.MCT-19-0520. Epub 2019 Aug 14. Mol Cancer Ther. 2019. PMID: 31413177 Free PMC article.
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