Routh ED - Search Results

1

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1.

Routh ED, Creacy SD, Beerbower PE, Akman SA, Vaughn JP, Smaldino PJ. Routh ED, et al. J Vis Exp. 2017 Mar 18;(121):55496. doi: 10.3791/55496. J Vis Exp. 2017. PMID: 28362374 Free PMC article.

2

The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.

Vaughn JP, Creacy SD, Routh ED, Joyner-Butt C, Jenkins GS, Pauli S, Nagamine Y, Akman SA. Vaughn JP, et al. Among authors: routh ed. J Biol Chem. 2005 Nov 18;280(46):38117-20. doi: 10.1074/jbc.C500348200. Epub 2005 Sep 7. J Biol Chem. 2005. PMID: 16150737 Free article.

3

G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates.

Creacy SD, Routh ED, Iwamoto F, Nagamine Y, Akman SA, Vaughn JP. Creacy SD, et al. Among authors: routh ed. J Biol Chem. 2008 Dec 12;283(50):34626-34. doi: 10.1074/jbc.M806277200. Epub 2008 Oct 7. J Biol Chem. 2008. PMID: 18842585 Free PMC article.

4

G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. Giri B, et al. Among authors: routh ed. Nucleic Acids Res. 2011 Sep 1;39(16):7161-78. doi: 10.1093/nar/gkr234. Epub 2011 May 17. Nucleic Acids Res. 2011. PMID: 21586581 Free PMC article.

5

Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.

Smaldino PJ, Routh ED, Kim JH, Giri B, Creacy SD, Hantgan RR, Akman SA, Vaughn JP. Smaldino PJ, et al. Among authors: routh ed. PLoS One. 2015 Jul 14;10(7):e0132668. doi: 10.1371/journal.pone.0132668. eCollection 2015. PLoS One. 2015. PMID: 26172836 Free PMC article.

6

G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells.

Richardson AE, Zentz ZA, Chambers AE, Sandwith SN, Reisinger MA, Saunders DW, Tompkins JD, Riggs AD, Routh ED, Rubenstein EM, Smaldino MA, Vaughn JP, Haney RA, Smaldino PJ. Richardson AE, et al. Among authors: routh ed. ACS Omega. 2020 Sep 16;5(38):24916-24926. doi: 10.1021/acsomega.0c03723. eCollection 2020 Sep 29. ACS Omega. 2020. PMID: 33015511 Free PMC article.

7

The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.

Tseng YJ, Sandwith SN, Green KM, Chambers AE, Krans A, Raimer HM, Sharlow ME, Reisinger MA, Richardson AE, Routh ED, Smaldino MA, Wang YH, Vaughn JP, Todd PK, Smaldino PJ. Tseng YJ, et al. Among authors: routh ed. J Biol Chem. 2021 Aug;297(2):100914. doi: 10.1016/j.jbc.2021.100914. Epub 2021 Jun 24. J Biol Chem. 2021. PMID: 34174288 Free PMC article.

8

Comprehensive Analysis of the Immunogenomics of Triple-Negative Breast Cancer Brain Metastases From LCCC1419.

Routh ED, Van Swearingen AED, Sambade MJ, Vensko S, McClure MB, Woodcock MG, Chai S, Cuaboy LA, Wheless A, Garrett A, Carey LA, Hoyle AP, Parker JS, Vincent BG, Anders CK. Routh ED, et al. Front Oncol. 2022 Jul 27;12:818693. doi: 10.3389/fonc.2022.818693. eCollection 2022. Front Oncol. 2022. PMID: 35992833 Free PMC article.

9

Prognostic attributes of immune signatures in soft tissue sarcomas show differential dependencies on tumor mutational burden.

Raj SKS, Routh ED, Chou JW, Votanopoulos KI, Triozzi PL, Miller LD. Raj SKS, et al. Among authors: routh ed. Cancer. 2022 Sep 1;128(17):3254-3264. doi: 10.1002/cncr.34333. Epub 2022 Jun 29. Cancer. 2022. PMID: 35767280 Free PMC article.

10

Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes.

Pullikuth AK, Routh ED, Zimmerman KD, Chifman J, Chou JW, Soike MH, Jin G, Su J, Song Q, Black MA, Print C, Bedognetti D, Howard-McNatt M, O'Neill SS, Thomas A, Langefeld CD, Sigalov AB, Lu Y, Miller LD. Pullikuth AK, et al. Among authors: routh ed. Front Oncol. 2021 Dec 8;11:734959. doi: 10.3389/fonc.2021.734959. eCollection 2021. Front Oncol. 2021. PMID: 34956864 Free PMC article.

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