Hazbun TR - Search Results

1

A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways.

Thomas FM, Goode KM, Rajwa B, Bieberich AA, Avramova LV, Hazbun TR, Davisson VJ. Thomas FM, et al. Among authors: hazbun tr. SLAS Discov. 2017 Jul;22(6):706-719. doi: 10.1177/2472555216687525. Epub 2017 Jan 31. SLAS Discov. 2017. PMID: 28346089 Free PMC article.

2

Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation.

Goode KM, Petrov DP, Vickman RE, Crist SA, Pascuzzi PE, Ratliff TL, Davisson VJ, Hazbun TR. Goode KM, et al. Among authors: hazbun tr. Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1992-2006. doi: 10.1016/j.bbagen.2017.05.006. Epub 2017 May 8. Biochim Biophys Acta Gen Subj. 2017. PMID: 28495207 Free PMC article.

3

Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process.

Tsai CJ, Aslam K, Drendel HM, Asiago JM, Goode KM, Paul LN, Rochet JC, Hazbun TR. Tsai CJ, et al. Among authors: hazbun tr. J Biol Chem. 2015 Oct 9;290(41):24816-34. doi: 10.1074/jbc.M115.678367. Epub 2015 Aug 25. J Biol Chem. 2015. PMID: 26306045 Free PMC article.

4

Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.

Thangamani S, Eldesouky HE, Mohammad H, Pascuzzi PE, Avramova L, Hazbun TR, Seleem MN. Thangamani S, et al. Among authors: hazbun tr. Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3002-3010. doi: 10.1016/j.bbagen.2016.09.029. Epub 2016 Oct 3. Biochim Biophys Acta Gen Subj. 2017. PMID: 27712973 Free PMC article.

5

Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway.

Thangamani S, Maland M, Mohammad H, Pascuzzi PE, Avramova L, Koehler CM, Hazbun TR, Seleem MN. Thangamani S, et al. Among authors: hazbun tr. Front Cell Infect Microbiol. 2017 Jan 18;7:4. doi: 10.3389/fcimb.2017.00004. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28149831 Free PMC article.

6

A yeast two-hybrid smart-pool-array system for protein-interaction mapping.

Jin F, Avramova L, Huang J, Hazbun T. Jin F, et al. Nat Methods. 2007 May;4(5):405-7. doi: 10.1038/nmeth1042. Epub 2007 Apr 22. Nat Methods. 2007. PMID: 17450148 Free PMC article.

7

The small heat shock protein Hsp31 cooperates with Hsp104 to modulate Sup35 prion aggregation.

Aslam K, Tsai CJ, Hazbun TR. Aslam K, et al. Among authors: hazbun tr. Prion. 2016 Nov;10(6):444-465. doi: 10.1080/19336896.2016.1234574. Prion. 2016. PMID: 27690738 Free PMC article.

8

Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity.

Aslam K, Hazbun TR. Aslam K, et al. Among authors: hazbun tr. Prion. 2016 Mar 3;10(2):103-11. doi: 10.1080/19336896.2016.1141858. Prion. 2016. PMID: 27097320 Free PMC article.

9

Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis.

Mohammad H, Elghazawy NH, Eldesouky HE, Hegazy YA, Younis W, Avrimova L, Hazbun T, Arafa RK, Seleem MN. Mohammad H, et al. ACS Infect Dis. 2018 Mar 9;4(3):403-414. doi: 10.1021/acsinfecdis.7b00215. Epub 2018 Feb 2. ACS Infect Dis. 2018. PMID: 29370698 Free PMC article.

10

Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species.

Eldesouky HE, Salama EA, Li X, Hazbun TR, Mayhoub AS, Seleem MN. Eldesouky HE, et al. Among authors: hazbun tr. Sci Rep. 2020 May 5;10(1):7525. doi: 10.1038/s41598-020-64571-7. Sci Rep. 2020. PMID: 32372011 Free PMC article.

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