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Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.
Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F. Leoni AL, et al. Among authors: colledge wh. PLoS One. 2010 Feb 19;5(2):e9298. doi: 10.1371/journal.pone.0009298. PLoS One. 2010. PMID: 20174578 Free PMC article.
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.
Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AE, Huang CL, Vandenberg JI, Colledge WH, Grace AA. Papadatos GA, et al. Among authors: colledge wh. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6210-5. doi: 10.1073/pnas.082121299. Epub 2002 Apr 23. Proc Natl Acad Sci U S A. 2002. PMID: 11972032 Free PMC article.
Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis.
Royer A, van Veen TA, Le Bouter S, Marionneau C, Griol-Charhbili V, Léoni AL, Steenman M, van Rijen HV, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JM, Grace AA, Escande D, Charpentier F. Royer A, et al. Among authors: colledge wh. Circulation. 2005 Apr 12;111(14):1738-46. doi: 10.1161/01.CIR.0000160853.19867.61. Epub 2005 Apr 4. Circulation. 2005. PMID: 15809371
Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.
Thomas G, Gurung IS, Killeen MJ, Hakim P, Goddard CA, Mahaut-Smith MP, Colledge WH, Grace AA, Huang CL. Thomas G, et al. Among authors: colledge wh. J Physiol. 2007 Jan 1;578(Pt 1):85-97. doi: 10.1113/jphysiol.2006.121921. Epub 2006 Nov 16. J Physiol. 2007. PMID: 17110414 Free PMC article.
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging.
van Veen TA, Stein M, Royer A, Le Quang K, Charpentier F, Colledge WH, Huang CL, Wilders R, Grace AA, Escande D, de Bakker JM, van Rijen HV. van Veen TA, et al. Among authors: colledge wh. Circulation. 2005 Sep 27;112(13):1927-35. doi: 10.1161/CIRCULATIONAHA.105.539072. Epub 2005 Sep 19. Circulation. 2005. PMID: 16172272
174 results