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A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E. Evnouchidou I, et al. Among authors: georgiadis d. J Immunol. 2012 Sep 1;189(5):2383-92. doi: 10.4049/jimmunol.1200918. Epub 2012 Jul 25. J Immunol. 2012. PMID: 22837489 Free PMC article.
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.
Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E. Zervoudi E, et al. Among authors: georgiadis d. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19890-5. doi: 10.1073/pnas.1309781110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248368 Free PMC article.
Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.
Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A. Aldhamen YA, et al. Among authors: georgiadis d. J Innate Immun. 2015;7(3):275-89. doi: 10.1159/000368899. Epub 2015 Jan 14. J Innate Immun. 2015. PMID: 25591727 Free PMC article.
Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.
Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D. Kokkala P, et al. Among authors: georgiadis d. J Med Chem. 2016 Oct 13;59(19):9107-9123. doi: 10.1021/acs.jmedchem.6b01031. Epub 2016 Sep 20. J Med Chem. 2016. PMID: 27606717
213 results