Carlile DJ - Search Results

1

Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas.

Patel YT, Daryani VM, Patel P, Zhou D, Fangusaro J, Carlile DJ, Martin PD, Aarons L, Stewart CF. Patel YT, et al. Among authors: carlile dj. CPT Pharmacometrics Syst Pharmacol. 2017 May;6(5):305-314. doi: 10.1002/psp4.12175. Epub 2017 Mar 22. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28326681 Free PMC article. Clinical Trial.

2

Pharmacokinetics and pharmacogenetics of the MEK1/2 inhibitor, selumetinib, in Asian and Western healthy subjects: a pooled analysis.

Dymond AW, Elks C, Martin P, Carlile DJ, Mariani G, Lovick S, Huang Y, Lorch U, Brown H, So K. Dymond AW, et al. Among authors: carlile dj. Eur J Clin Pharmacol. 2017 Jun;73(6):717-726. doi: 10.1007/s00228-017-2217-3. Epub 2017 Mar 10. Eur J Clin Pharmacol. 2017. PMID: 28283692 Free PMC article.

3

Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials.

Patel P, Howgate E, Martin P, Carlile DJ, Aarons L, Zhou D. Patel P, et al. Among authors: carlile dj. Br J Clin Pharmacol. 2018 Jan;84(1):52-63. doi: 10.1111/bcp.13404. Epub 2017 Sep 22. Br J Clin Pharmacol. 2018. PMID: 28833380 Free PMC article.

4

Population Pharmacokinetic and Exposure-Response Analysis of Selumetinib and Its N-desmethyl Metabolite in Patients With Non-Small Cell Lung Cancer.

Tong X, Xu H, Carlile DJ, Tomkinson H, Al-Huniti N, Zhou D. Tong X, et al. Among authors: carlile dj. J Clin Pharmacol. 2019 Jan;59(1):112-122. doi: 10.1002/jcph.1295. Epub 2018 Aug 13. J Clin Pharmacol. 2019. PMID: 30102413 Clinical Trial.

5

Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab.

Djebli N, Parrott N, Jaminion F, O'Jeanson A, Guerini E, Carlile D. Djebli N, et al. CPT Pharmacometrics Syst Pharmacol. 2024 Mar;13(3):396-409. doi: 10.1002/psp4.13091. Epub 2023 Dec 14. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38044486 Free PMC article.

6

Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma and Exposure-Response in CLL.

Gibiansky E, Gibiansky L, Carlile DJ, Jamois C, Buchheit V, Frey N. Gibiansky E, et al. Among authors: carlile dj. CPT Pharmacometrics Syst Pharmacol. 2014 Oct 29;3(10):e144. doi: 10.1038/psp.2014.42. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25353187 Free PMC article.

7

Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue.

Stroh M, Carlile DJ, Li CC, Wagg J, Ribba B, Ramanujan S, Jin J, Xu J, Charoin JE, Xhu ZX, Morcos PN, Davis JD, Phipps A. Stroh M, et al. Among authors: carlile dj. CPT Pharmacometrics Syst Pharmacol. 2015 Sep;4(9):495-7. doi: 10.1002/psp4.12014. Epub 2015 Sep 11. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26451328 Free PMC article.

8

SELECT-2: a phase II, double-blind, randomized, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment of patients with advanced or metastatic non-small-cell lung cancer.

Soria JC, Fülöp A, Maciel C, Fischer JR, Girotto G, Lago S, Smit E, Ostoros G, Eberhardt WEE, Lishkovska P, Lovick S, Mariani G, McKeown A, Kilgour E, Smith P, Bowen K, Kohlmann A, Carlile DJ, Jänne PA. Soria JC, et al. Among authors: carlile dj. Ann Oncol. 2017 Dec 1;28(12):3028-3036. doi: 10.1093/annonc/mdx628. Ann Oncol. 2017. PMID: 29045535 Free PMC article. Clinical Trial.

9

Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data.

Ashforth EI, Carlile DJ, Chenery R, Houston JB. Ashforth EI, et al. Among authors: carlile dj. J Pharmacol Exp Ther. 1995 Aug;274(2):761-6. J Pharmacol Exp Ther. 1995. PMID: 7636740

10

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices.

Houston JB, Carlile DJ. Houston JB, et al. Among authors: carlile dj. Drug Metab Rev. 1997 Nov;29(4):891-922. doi: 10.3109/03602539709002237. Drug Metab Rev. 1997. PMID: 9421679 Review. No abstract available.

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