Bachmann F - Search Results

1

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.

Vuorinen A, Engeli RT, Leugger S, Bachmann F, Akram M, Atanasov AG, Waltenberger B, Temml V, Stuppner H, Krenn L, Ateba SB, Njamen D, Davis RA, Odermatt A, Schuster D. Vuorinen A, et al. Among authors: bachmann f. J Nat Prod. 2017 Apr 28;80(4):965-974. doi: 10.1021/acs.jnatprod.6b00950. Epub 2017 Mar 20. J Nat Prod. 2017. PMID: 28319389 Free PMC article.

2

Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17β-hydroxysteroid dehydrogenase 2 inhibitors.

Vuorinen A, Engeli R, Meyer A, Bachmann F, Griesser UJ, Schuster D, Odermatt A. Vuorinen A, et al. Among authors: bachmann f. J Med Chem. 2014 Jul 24;57(14):5995-6007. doi: 10.1021/jm5004914. Epub 2014 Jul 10. J Med Chem. 2014. PMID: 24960438 Free PMC article.

3

Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine.

Bachmann F, Meyer Zu Schwabedissen HE, Duthaler U, Krähenbühl S. Bachmann F, et al. Br J Clin Pharmacol. 2022 Feb;88(4):1885-1896. doi: 10.1111/bcp.15108. Epub 2021 Nov 7. Br J Clin Pharmacol. 2022. PMID: 34648192 Free PMC article. Clinical Trial.

4

N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole.

Bachmann F, Duthaler U, Rudin D, Krähenbühl S, Haschke M. Bachmann F, et al. Eur J Pharm Sci. 2018 Jul 30;120:172-180. doi: 10.1016/j.ejps.2018.05.003. Epub 2018 May 8. Eur J Pharm Sci. 2018. PMID: 29746911

5

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug.

Berger B, Bachmann F, Duthaler U, Krähenbühl S, Haschke M. Berger B, et al. Among authors: bachmann f. Front Pharmacol. 2018 Jul 24;9:774. doi: 10.3389/fphar.2018.00774. eCollection 2018. Front Pharmacol. 2018. PMID: 30087611 Free PMC article.

6

Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells.

Rudin D, Lanzilotto A, Bachmann F, Housecroft CE, Constable EC, Drewe J, Haschke M, Krähenbühl S. Rudin D, et al. Among authors: bachmann f. Biochem Pharmacol. 2019 May;163:345-356. doi: 10.1016/j.bcp.2019.01.011. Epub 2019 Jan 14. Biochem Pharmacol. 2019. PMID: 30653950 Free article.

7

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study.

Ziesenitz VC, Rodieux F, Atkinson A, Borter C, Bielicki JA, Haschke M, Duthaler U, Bachmann F, Erb TO, Gürtler N, Holland-Cunz S, van den Anker JN, Gotta V, Pfister M. Ziesenitz VC, et al. Among authors: bachmann f. Eur J Clin Pharmacol. 2019 Nov;75(11):1491-1502. doi: 10.1007/s00228-019-02720-2. Epub 2019 Aug 7. Eur J Clin Pharmacol. 2019. PMID: 31388703 Free article. Clinical Trial.

8

Development and validation of an LC-MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma.

Bachmann F, Blaser L, Haschke M, Krähenbühl S, Duthaler U. Bachmann F, et al. Bioanalysis. 2020 Feb;12(3):175-189. doi: 10.4155/bio-2019-0251. Epub 2020 Feb 13. Bioanalysis. 2020. PMID: 32052638

9

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.

Bachmann F, Duthaler U, Meyer Zu Schwabedissen HE, Puchkov M, Huwyler J, Haschke M, Krähenbühl S. Bachmann F, et al. Clin Pharmacol Ther. 2021 Jun;109(6):1505-1516. doi: 10.1002/cpt.2141. Epub 2021 Jan 19. Clin Pharmacol Ther. 2021. PMID: 33336382 Free PMC article.

10

Effect of deglucuronidation on the results of the Basel phenotyping cocktail.

Bachmann F, Duthaler U, Krähenbühl S. Bachmann F, et al. Br J Clin Pharmacol. 2021 Dec;87(12):4608-4618. doi: 10.1111/bcp.14874. Epub 2021 May 7. Br J Clin Pharmacol. 2021. PMID: 33890704 Free article.

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