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The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.
Schoenfeld HA, West T, Verghese PB, Holubasch M, Shenoy N, Kagan D, Buono C, Zhou W, DeCristofaro M, Douville J, Goodrich GG, Mansfield K, Saravanan C, Cumin F, Webb RL, Bateman RJ. Schoenfeld HA, et al. Among authors: zhou w. Toxicol Appl Pharmacol. 2017 May 15;323:53-65. doi: 10.1016/j.taap.2017.03.014. Epub 2017 Mar 15. Toxicol Appl Pharmacol. 2017. PMID: 28315356 Free article.
Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects.
Gan L, Jiang X, Mendonza A, Swan T, Reynolds C, Nguyen J, Pal P, Neelakantham S, Dahlke M, Langenickel T, Rajman I, Akahori M, Zhou W, Rebello S, Sunkara G. Gan L, et al. Among authors: zhou w. Clin Pharmacol Drug Dev. 2016 Jan;5(1):27-39. doi: 10.1002/cpdd.181. Epub 2015 Nov 4. Clin Pharmacol Drug Dev. 2016. PMID: 27119576 Clinical Trial.
Evaluation of Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension.
Hsiao HL, Langenickel TH, Petruck J, Kode K, Ayalasomayajula S, Schuehly U, Greeley M, Pal P, Zhou W, Prescott MF, Sunkara G, Rajman I. Hsiao HL, et al. Among authors: zhou w. Clin Pharmacol Ther. 2018 Mar;103(3):468-476. doi: 10.1002/cpt.759. Epub 2017 Nov 3. Clin Pharmacol Ther. 2018. PMID: 28599060 Free PMC article. Clinical Trial.
Assessment of Drug-Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects.
Ayalasomayajula S, Pan W, Han Y, Yang F, Langenickel T, Pal P, Zhou W, Yuan Y, Rajman I, Sunkara G. Ayalasomayajula S, et al. Among authors: zhou w. Eur J Drug Metab Pharmacokinet. 2017 Apr;42(2):309-318. doi: 10.1007/s13318-016-0349-y. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27245340 Clinical Trial.
Vascular origin of vildagliptin-induced skin effects in Cynomolgus monkeys: pathomechanistic role of peripheral sympathetic system and neuropeptide Y.
Hoffmann P, Bentley P, Sahota P, Schoenfeld H, Martin L, Longo L, Spaet R, Moulin P, Pantano S, Dubost V, Lapadula D, Burkey B, Kaushik V, Zhou W, Hayes M, Flavahan N, Chibout SD, Busch S. Hoffmann P, et al. Among authors: zhou w. Toxicol Pathol. 2014 Jun;42(4):684-95. doi: 10.1177/0192623313516828. Epub 2014 Jan 20. Toxicol Pathol. 2014. PMID: 24448599
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