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The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.
Schoenfeld HA, West T, Verghese PB, Holubasch M, Shenoy N, Kagan D, Buono C, Zhou W, DeCristofaro M, Douville J, Goodrich GG, Mansfield K, Saravanan C, Cumin F, Webb RL, Bateman RJ. Schoenfeld HA, et al. Among authors: west t. Toxicol Appl Pharmacol. 2017 May 15;323:53-65. doi: 10.1016/j.taap.2017.03.014. Epub 2017 Mar 15. Toxicol Appl Pharmacol. 2017. PMID: 28315356 Free article.
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Castellano JM, et al. Among authors: west t. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15502-7. doi: 10.1073/pnas.1206446109. Epub 2012 Aug 27. Proc Natl Acad Sci U S A. 2012. PMID: 22927427 Free PMC article.
An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.
Sheline YI, West T, Yarasheski K, Swarm R, Jasielec MS, Fisher JR, Ficker WD, Yan P, Xiong C, Frederiksen C, Grzelak MV, Chott R, Bateman RJ, Morris JC, Mintun MA, Lee JM, Cirrito JR. Sheline YI, et al. Among authors: west t. Sci Transl Med. 2014 May 14;6(236):236re4. doi: 10.1126/scitranslmed.3008169. Sci Transl Med. 2014. PMID: 24828079 Free PMC article. Clinical Trial.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.
Yanamandra K, Patel TK, Jiang H, Schindler S, Ulrich JD, Boxer AL, Miller BL, Kerwin DR, Gallardo G, Stewart F, Finn MB, Cairns NJ, Verghese PB, Fogelman I, West T, Braunstein J, Robinson G, Keyser J, Roh J, Knapik SS, Hu Y, Holtzman DM. Yanamandra K, et al. Among authors: west t. Sci Transl Med. 2017 Apr 19;9(386):eaal2029. doi: 10.1126/scitranslmed.aal2029. Sci Transl Med. 2017. PMID: 28424326 Free PMC article.
SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.
Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ. Paterson RW, et al. Among authors: west t. Nat Rev Neurol. 2019 Jul;15(7):419-427. doi: 10.1038/s41582-019-0222-0. Epub 2019 Jun 20. Nat Rev Neurol. 2019. PMID: 31222062 Free PMC article. Review.
A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis.
West T, Kirmess KM, Meyer MR, Holubasch MS, Knapik SS, Hu Y, Contois JH, Jackson EN, Harpstrite SE, Bateman RJ, Holtzman DM, Verghese PB, Fogelman I, Braunstein JB, Yarasheski KE. West T, et al. Mol Neurodegener. 2021 May 1;16(1):30. doi: 10.1186/s13024-021-00451-6. Mol Neurodegener. 2021. PMID: 33933117 Free PMC article.
The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis.
Kirmess KM, Meyer MR, Holubasch MS, Knapik SS, Hu Y, Jackson EN, Harpstrite SE, Verghese PB, West T, Fogelman I, Braunstein JB, Yarasheski KE, Contois JH. Kirmess KM, et al. Among authors: west t. Clin Chim Acta. 2021 Aug;519:267-275. doi: 10.1016/j.cca.2021.05.011. Epub 2021 May 17. Clin Chim Acta. 2021. PMID: 34015303 Free PMC article.
1,017 results