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Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG. Seixas da Silva GS, et al. Among authors: lyra e silva nm. J Biol Chem. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525. Epub 2017 Mar 16. J Biol Chem. 2017. PMID: 28302722 Free PMC article.
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Forny-Germano L, et al. Among authors: lyra e silva nm. J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014. J Neurosci. 2014. PMID: 25297091 Free PMC article.
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Clarke JR, et al. Among authors: lyra e silva nm. EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183. EMBO Mol Med. 2015. PMID: 25617315 Free PMC article.
A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.
Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL. Sebollela A, et al. Among authors: lyra e silva nm. J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2. J Neurochem. 2017. PMID: 28670737 Free PMC article.
The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.
Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Batista AF, et al. Among authors: lyra e silva nm. J Pathol. 2018 May;245(1):85-100. doi: 10.1002/path.5056. Epub 2018 Apr 2. J Pathol. 2018. PMID: 29435980 Free PMC article.
Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.
Frost PS, Barros-Aragão F, da Silva RT, Venancio A, Matias I, Lyra E Silva NM, Kincheski GC, Pimentel-Coelho PM, De Felice FG, Gomes FCA, Ferreira ST, Figueiredo CP, Clarke JR. Frost PS, et al. Among authors: lyra e silva nm. Cell Death Dis. 2019 Apr 11;10(4):323. doi: 10.1038/s41419-019-1529-x. Cell Death Dis. 2019. PMID: 30975983 Free PMC article.
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.
Lyra E Silva NM, Gonçalves RA, Pascoal TA, Lima-Filho RAS, Resende EPF, Vieira ELM, Teixeira AL, de Souza LC, Peny JA, Fortuna JTS, Furigo IC, Hashiguchi D, Miya-Coreixas VS, Clarke JR, Abisambra JF, Longo BM, Donato J Jr, Fraser PE, Rosa-Neto P, Caramelli P, Ferreira ST, De Felice FG. Lyra E Silva NM, et al. Transl Psychiatry. 2021 Apr 28;11(1):251. doi: 10.1038/s41398-021-01349-z. Transl Psychiatry. 2021. PMID: 33911072 Free PMC article.
Editorial: The Impact of Obesity on Cognitive Function.
Melo HM, Lyra E Silva NM, Grillo CA. Melo HM, et al. Among authors: lyra e silva nm. Front Neurosci. 2022 Jun 15;16:916243. doi: 10.3389/fnins.2022.916243. eCollection 2022. Front Neurosci. 2022. PMID: 35784840 Free PMC article. No abstract available.
17 results