Gradinaru V - Search Results

1

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins.

Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Bedbrook CN, et al. Among authors: gradinaru v. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2624-E2633. doi: 10.1073/pnas.1700269114. Epub 2017 Mar 10. Proc Natl Acad Sci U S A. 2017. PMID: 28283661 Free PMC article.

2

Directed evolution of a far-red fluorescent rhodopsin.

McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH. McIsaac RS, et al. Among authors: gradinaru v. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13034-9. doi: 10.1073/pnas.1413987111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157169 Free PMC article.

3

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons.

Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V. Flytzanis NC, et al. Among authors: gradinaru v. Nat Commun. 2014 Sep 15;5:4894. doi: 10.1038/ncomms5894. Nat Commun. 2014. PMID: 25222271 Free PMC article.

4

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo.

Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Bedbrook CN, et al. Among authors: gradinaru v. Chem Biol. 2015 Aug 20;22(8):1108-21. doi: 10.1016/j.chembiol.2015.06.020. Epub 2015 Jul 23. Chem Biol. 2015. PMID: 26211362 Free PMC article.

5

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JKB, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Herwig L, et al. Among authors: gradinaru v. Cell Chem Biol. 2017 Mar 16;24(3):415-425. doi: 10.1016/j.chembiol.2017.02.008. Epub 2017 Mar 2. Cell Chem Biol. 2017. PMID: 28262559 Free PMC article.

6

The Jellyfish Cassiopea Exhibits a Sleep-like State.

Nath RD, Bedbrook CN, Abrams MJ, Basinger T, Bois JS, Prober DA, Sternberg PW, Gradinaru V, Goentoro L. Nath RD, et al. Among authors: gradinaru v. Curr Biol. 2017 Oct 9;27(19):2984-2990.e3. doi: 10.1016/j.cub.2017.08.014. Epub 2017 Sep 21. Curr Biol. 2017. PMID: 28943083 Free PMC article.

7

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

Bedbrook CN, Yang KK, Rice AJ, Gradinaru V, Arnold FH. Bedbrook CN, et al. Among authors: gradinaru v. PLoS Comput Biol. 2017 Oct 23;13(10):e1005786. doi: 10.1371/journal.pcbi.1005786. eCollection 2017 Oct. PLoS Comput Biol. 2017. PMID: 29059183 Free PMC article.

8

Viral Strategies for Targeting the Central and Peripheral Nervous Systems.

Bedbrook CN, Deverman BE, Gradinaru V. Bedbrook CN, et al. Among authors: gradinaru v. Annu Rev Neurosci. 2018 Jul 8;41:323-348. doi: 10.1146/annurev-neuro-080317-062048. Epub 2018 Apr 25. Annu Rev Neurosci. 2018. PMID: 29709207 Review.

9

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.

Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH. Bedbrook CN, et al. Among authors: gradinaru v. Nat Methods. 2019 Nov;16(11):1176-1184. doi: 10.1038/s41592-019-0583-8. Epub 2019 Oct 14. Nat Methods. 2019. PMID: 31611694 Free PMC article.

10

Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types.

Ravindra Kumar S, Miles TF, Chen X, Brown D, Dobreva T, Huang Q, Ding X, Luo Y, Einarsson PH, Greenbaum A, Jang MJ, Deverman BE, Gradinaru V. Ravindra Kumar S, et al. Among authors: gradinaru v. Nat Methods. 2020 May;17(5):541-550. doi: 10.1038/s41592-020-0799-7. Epub 2020 Apr 20. Nat Methods. 2020. PMID: 32313222 Free PMC article.

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