Geertsema EM - Search Results

1

Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase.

Rahimi M, Geertsema EM, Miao Y, van der Meer JY, van den Bosch T, de Haan P, Zandvoort E, Poelarends GJ. Rahimi M, et al. Among authors: geertsema em. Org Biomol Chem. 2017 Mar 28;15(13):2809-2816. doi: 10.1039/c7ob00302a. Org Biomol Chem. 2017. PMID: 28277572

2

Bridging between organocatalysis and biocatalysis: asymmetric addition of acetaldehyde to β-nitrostyrenes catalyzed by a promiscuous proline-based tautomerase.

Zandvoort E, Geertsema EM, Baas BJ, Quax WJ, Poelarends GJ. Zandvoort E, et al. Among authors: geertsema em. Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1240-3. doi: 10.1002/anie.201107404. Epub 2011 Dec 21. Angew Chem Int Ed Engl. 2012. PMID: 22190406 No abstract available.

3

Enhancement of the promiscuous aldolase and dehydration activities of 4-oxalocrotonate tautomerase by protein engineering.

Zandvoort E, Geertsema EM, Quax WJ, Poelarends GJ. Zandvoort E, et al. Among authors: geertsema em. Chembiochem. 2012 Jun 18;13(9):1274-7. doi: 10.1002/cbic.201200225. Epub 2012 May 21. Chembiochem. 2012. PMID: 22615135

4

An unexpected promiscuous activity of 4-oxalocrotonate tautomerase: the cis-trans isomerisation of nitrostyrene.

Zandvoort E, Geertsema EM, Baas BJ, Quax WJ, Poelarends GJ. Zandvoort E, et al. Among authors: geertsema em. Chembiochem. 2012 Sep 3;13(13):1869-73. doi: 10.1002/cbic.201200371. Epub 2012 Jul 31. Chembiochem. 2012. PMID: 22851288

5

Promiscuous catalysis of asymmetric Michael-type additions of linear aldehydes to β-nitrostyrene by the proline-based enzyme 4-oxalocrotonate tautomerase.

Miao Y, Geertsema EM, Tepper PG, Zandvoort E, Poelarends GJ. Miao Y, et al. Among authors: geertsema em. Chembiochem. 2013 Jan 21;14(2):191-4. doi: 10.1002/cbic.201200676. Epub 2013 Jan 9. Chembiochem. 2013. PMID: 23303727

6

Recent advances in the study of enzyme promiscuity in the tautomerase superfamily.

Baas BJ, Zandvoort E, Geertsema EM, Poelarends GJ. Baas BJ, et al. Among authors: geertsema em. Chembiochem. 2013 May 27;14(8):917-26. doi: 10.1002/cbic.201300098. Epub 2013 May 3. Chembiochem. 2013. PMID: 23649962 Review.

7

Biocatalytic Michael-type additions of acetaldehyde to nitroolefins with the proline-based enzyme 4-oxalocrotonate tautomerase yielding enantioenriched γ-nitroaldehydes.

Geertsema EM, Miao Y, Tepper PG, de Haan P, Zandvoort E, Poelarends GJ. Geertsema EM, et al. Chemistry. 2013 Oct 18;19(43):14407-10. doi: 10.1002/chem.201302351. Epub 2013 Sep 24. Chemistry. 2013. PMID: 24115023

8

Evidence for the formation of an enamine species during aldol and Michael-type addition reactions promiscuously catalyzed by 4-oxalocrotonate tautomerase.

Poddar H, Rahimi M, Geertsema EM, Thunnissen AM, Poelarends GJ. Poddar H, et al. Among authors: geertsema em. Chembiochem. 2015 Mar 23;16(5):738-41. doi: 10.1002/cbic.201402687. Epub 2015 Feb 26. Chembiochem. 2015. PMID: 25728471

9

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.

van der Meer JY, Poddar H, Baas BJ, Miao Y, Rahimi M, Kunzendorf A, van Merkerk R, Tepper PG, Geertsema EM, Thunnissen AM, Quax WJ, Poelarends GJ. van der Meer JY, et al. Among authors: geertsema em. Nat Commun. 2016 Mar 8;7:10911. doi: 10.1038/ncomms10911. Nat Commun. 2016. PMID: 26952338 Free PMC article.

10

Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations.

Rahimi M, van der Meer JY, Geertsema EM, Poddar H, Baas BJ, Poelarends GJ. Rahimi M, et al. Among authors: geertsema em. Chembiochem. 2016 Jul 1;17(13):1225-8. doi: 10.1002/cbic.201600149. Epub 2016 May 30. Chembiochem. 2016. PMID: 27238293

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