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BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov AN, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh MJ, Zhang DY, Xiong H, Zhou MM. Cheung K, et al. Among authors: jaganathan a. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957. doi: 10.1073/pnas.1615601114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265070 Free PMC article.
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren C, Kaplan MH, He JC, Xiong H, Zhou MM. Cheung KL, et al. Among authors: jaganathan a. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2117112119. doi: 10.1073/pnas.2117112119. Epub 2022 Mar 28. Proc Natl Acad Sci U S A. 2022. PMID: 35344430 Free PMC article.
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM. Cheung KL, et al. Among authors: jaganathan a. Mol Cell. 2017 Mar 16;65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3. Mol Cell. 2017. PMID: 28262505 Free PMC article.
32 results