Edginton AN - Search Results

1

Population PBPK modelling of trastuzumab: a framework for quantifying and predicting inter-individual variability.

Malik PRV, Hamadeh A, Phipps C, Edginton AN. Malik PRV, et al. Among authors: edginton an. J Pharmacokinet Pharmacodyn. 2017 Jun;44(3):277-290. doi: 10.1007/s10928-017-9515-3. Epub 2017 Mar 4. J Pharmacokinet Pharmacodyn. 2017. PMID: 28260166

2

Canadian clinical experience on switching from standard half-life recombinant factor VIII (rFVIII), octocog alfa, to extended half-life rFVIII, damoctocog alfa pegol, in persons with haemophilia A ≥ 12 years followed in a Comprehensive Hemophilia Care Program in Canada.

Matino D, Germini F, Chan AKC, Decker K, Iserman E, Chelle P, Edginton AN, Oladoyinbo O, Trinari E, Keepanasseril A, Iorio A. Matino D, et al. Among authors: edginton an. Haemophilia. 2024 Mar;30(2):345-354. doi: 10.1111/hae.14960. Epub 2024 Feb 20. Haemophilia. 2024. PMID: 38379181

3

Development of a Plasminogen Population PK model supporting prophylactic replacement therapy for Plasminogen deficient patients within the WAPPS-Hemo platform.

Chelle P, Hajducek D, Thibaudeau K, Hobson N, Iorio A, Shapiro A, Edginton A. Chelle P, et al. Haemophilia. 2024 Jul;30(4):988-997. doi: 10.1111/hae.15027. Epub 2024 May 2. Haemophilia. 2024. PMID: 38698539

4

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

Willmann S, Höhn K, Edginton A, Sevestre M, Solodenko J, Weiss W, Lippert J, Schmitt W. Willmann S, et al. J Pharmacokinet Pharmacodyn. 2007 Jun;34(3):401-31. doi: 10.1007/s10928-007-9053-5. Epub 2007 Mar 13. J Pharmacokinet Pharmacodyn. 2007. PMID: 17431751

5

The integration of allometry and virtual populations to predict clearance and clearance variability in pediatric populations over the age of 6 years.

Edginton AN, Shah B, Sevestre M, Momper JD. Edginton AN, et al. Clin Pharmacokinet. 2013 Aug;52(8):693-703. doi: 10.1007/s40262-013-0065-6. Clin Pharmacokinet. 2013. PMID: 23588537

6

Development of a decision tree to classify the most accurate tissue-specific tissue to plasma partition coefficient algorithm for a given compound.

Yun YE, Cotton CA, Edginton AN. Yun YE, et al. Among authors: edginton an. J Pharmacokinet Pharmacodyn. 2014 Feb;41(1):1-14. doi: 10.1007/s10928-013-9342-0. Epub 2013 Nov 21. J Pharmacokinet Pharmacodyn. 2014. PMID: 24258064

7

A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide.

Offman E, Edginton AN. Offman E, et al. Among authors: edginton an. J Pharmacokinet Pharmacodyn. 2015 Apr;42(2):135-50. doi: 10.1007/s10928-015-9406-4. Epub 2015 Feb 4. J Pharmacokinet Pharmacodyn. 2015. PMID: 25650156

8

Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide.

Offman E, Phipps C, Edginton AN. Offman E, et al. Among authors: edginton an. In Silico Pharmacol. 2016 Dec;4(1):3. doi: 10.1186/s40203-016-0018-5. Epub 2016 Mar 1. In Silico Pharmacol. 2016. PMID: 26932471 Free PMC article.

9

Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data.

Hornik CP, Wu H, Edginton AN, Watt K, Cohen-Wolkowiez M, Gonzalez D. Hornik CP, et al. Among authors: edginton an. Clin Pharmacokinet. 2017 Nov;56(11):1343-1353. doi: 10.1007/s40262-017-0525-5. Clin Pharmacokinet. 2017. PMID: 28290120 Free PMC article.

10

Pharmacokinetic Considerations for Antibody-Drug Conjugates against Cancer.

Malik P, Phipps C, Edginton A, Blay J. Malik P, et al. Pharm Res. 2017 Dec;34(12):2579-2595. doi: 10.1007/s11095-017-2259-3. Epub 2017 Sep 18. Pharm Res. 2017. PMID: 28924691 Review.

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