Ward KW - Search Results

1

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction.

Sharma A, Rizky L, Stefanovic N, Tate M, Ritchie RH, Ward KW, de Haan JB. Sharma A, et al. Among authors: ward kw. Cardiovasc Diabetol. 2017 Mar 3;16(1):33. doi: 10.1186/s12933-017-0513-y. Cardiovasc Diabetol. 2017. PMID: 28253885 Free PMC article.

2

Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease.

Tan SM, Sharma A, Stefanovic N, Yuen DY, Karagiannis TC, Meyer C, Ward KW, Cooper ME, de Haan JB. Tan SM, et al. Among authors: ward kw. Diabetes. 2014 Sep;63(9):3091-103. doi: 10.2337/db13-1743. Epub 2014 Apr 16. Diabetes. 2014. PMID: 24740568

3

A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy.

Deliyanti D, Lee JY, Petratos S, Meyer CJ, Ward KW, Wilkinson-Berka JL, de Haan JB. Deliyanti D, et al. Among authors: ward kw. Clin Sci (Lond). 2016 Aug 1;130(15):1375-87. doi: 10.1042/CS20160068. Epub 2016 Mar 22. Clin Sci (Lond). 2016. PMID: 27005782

4

Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy.

Deliyanti D, Alrashdi SF, Tan SM, Meyer C, Ward KW, de Haan JB, Wilkinson-Berka JL. Deliyanti D, et al. Among authors: ward kw. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):815-825. doi: 10.1167/iovs.17-22920. Invest Ophthalmol Vis Sci. 2018. PMID: 29411009

5

The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling.

Bubb KJ, Kok C, Tang O, Rasko NB, Birgisdottir AB, Hansen T, Ritchie R, Bhindi R, Reisman SA, Meyer C, Ward K, Karimi Galougahi K, Figtree GA. Bubb KJ, et al. Free Radic Biol Med. 2017 Jul;108:585-594. doi: 10.1016/j.freeradbiomed.2017.04.027. Epub 2017 Apr 21. Free Radic Biol Med. 2017. PMID: 28438659

6

Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.

Chin M, Lee CY, Chuang JC, Bumeister R, Wigley WC, Sonis ST, Ward KW, Meyer C. Chin M, et al. Among authors: ward kw. Am J Physiol Renal Physiol. 2013 Jun 15;304(12):F1438-46. doi: 10.1152/ajprenal.00387.2012. Epub 2013 Apr 17. Am J Physiol Renal Physiol. 2013. PMID: 23594825 Free article.

7

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

Reisman SA, Chertow GM, Hebbar S, Vaziri ND, Ward KW, Meyer CJ. Reisman SA, et al. Among authors: ward kw. J Am Soc Nephrol. 2012 Oct;23(10):1663-73. doi: 10.1681/ASN.2012050457. Epub 2012 Aug 2. J Am Soc Nephrol. 2012. PMID: 22859857 Free PMC article.

8

Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.

Li B, Abdalrahman A, Lai Y, Janicki JS, Ward KW, Meyer CJ, Wang XL, Tang D, Cui T. Li B, et al. Among authors: ward kw. Biochem Biophys Res Commun. 2014 Feb 21;444(4):555-61. doi: 10.1016/j.bbrc.2014.01.101. Epub 2014 Jan 29. Biochem Biophys Res Commun. 2014. PMID: 24486487

9

CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats.

Reisman SA, Ward KW, Klaassen CD, Meyer CJ. Reisman SA, et al. Among authors: ward kw. Xenobiotica. 2013 Jul;43(7):571-8. doi: 10.3109/00498254.2012.750022. Epub 2012 Dec 17. Xenobiotica. 2013. PMID: 23244591

10

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates.

Reisman SA, Gahir SS, Lee CI, Proksch JW, Sakamoto M, Ward KW. Reisman SA, et al. Among authors: ward kw. Drug Des Devel Ther. 2019 Apr 17;13:1259-1270. doi: 10.2147/DDDT.S193889. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31118567 Free PMC article. Clinical Trial.

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