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NRF2 as an Emerging Therapeutic Target.
Copple IM, Dinkova-Kostova AT, Kensler TW, Liby KT, Wigley WC. Copple IM, et al. Oxid Med Cell Longev. 2017;2017:8165458. doi: 10.1155/2017/8165458. Epub 2017 Jan 31. Oxid Med Cell Longev. 2017. PMID: 28250892 Free PMC article. No abstract available.
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. doi: 10.1073/pnas.0500815102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767573 Free PMC article.
The role of Keap1 in cellular protective responses.
Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB. Liby K, et al. Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123. Cancer Res. 2008. PMID: 18701497 Free PMC article.
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD. Chowdhry S, et al. Free Radic Biol Med. 2010 Jan 15;48(2):357-71. doi: 10.1016/j.freeradbiomed.2009.11.007. Epub 2009 Nov 13. Free Radic Biol Med. 2010. PMID: 19914374
194 results