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A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies.
Cukierman DS, Pinheiro AB, Castiñeiras-Filho SL, da Silva AS, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha AL, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, Rey NA. Cukierman DS, et al. Among authors: pereira md. J Inorg Biochem. 2017 May;170:160-168. doi: 10.1016/j.jinorgbio.2017.02.020. Epub 2017 Feb 22. J Inorg Biochem. 2017. PMID: 28249224
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF. Lázaro DF, et al. Among authors: pereira md. PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov. PLoS Genet. 2014. PMID: 25393002 Free PMC article.
A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity.
Queiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD. Queiroz DD, et al. Among authors: pereira md. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. doi: 10.1016/j.bbadis.2022.166475. Epub 2022 Jun 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35777688 Free article.
Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity.
Thornton L, Dixit V, Assad LO, Ribeiro TP, Queiroz DD, Kellett A, Casey A, Colleran J, Pereira MD, Rochford G, McCann M, O'Shea D, Dempsey R, McClean S, Kia AF, Walsh M, Creaven B, Howe O, Devereux M. Thornton L, et al. Among authors: pereira md. J Inorg Biochem. 2016 Jun;159:120-32. doi: 10.1016/j.jinorgbio.2016.02.024. Epub 2016 Mar 2. J Inorg Biochem. 2016. PMID: 26986979
188 results