Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase.
Ishii T, Tatsuda E, Kumazawa S, Nakayama T, Uchida K.
Ishii T, et al. Among authors: uchida k.
Biochemistry. 2003 Apr 1;42(12):3474-80. doi: 10.1021/bi027172o.
Biochemistry. 2003.
PMID: 12653551
It has been suggested that HNE exerts an inhibitory effect on the enzyme due to the modification of the cysteine residue (Cys-149) at the catalytic site generating the HNE-cysteine Michael addition-type adduct [Uchida, K., and Stadtman, E. R. (1993) J. Biol. Chem. 2 …
It has been suggested that HNE exerts an inhibitory effect on the enzyme due to the modification of the cysteine residue (Cys-149) at the ca …