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Page 1
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.
Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. Weismann D, et al. Among authors: binder cj. Nature. 2011 Oct 5;478(7367):76-81. doi: 10.1038/nature10449. Nature. 2011. PMID: 21979047 Free PMC article.
Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine.
Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Gonen A, et al. Among authors: binder cj. J Lipid Res. 2014 Oct;55(10):2137-55. doi: 10.1194/jlr.M053256. Epub 2014 Aug 20. J Lipid Res. 2014. PMID: 25143462 Free PMC article.
Malondialdehyde epitopes as mediators of sterile inflammation.
Busch CJ, Binder CJ. Busch CJ, et al. Among authors: binder cj. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Apr;1862(4):398-406. doi: 10.1016/j.bbalip.2016.06.016. Epub 2016 Jun 26. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 27355566 Review.
Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice.
Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weißer J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ. Busch CJ, et al. Among authors: binder cj. Hepatology. 2017 Apr;65(4):1181-1195. doi: 10.1002/hep.28970. Epub 2017 Feb 3. Hepatology. 2017. PMID: 27981604 Free PMC article.
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.
Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer FJ, Kiss MG, Enders L, Weißer J, Göderle L, Lambert J, Frommlet F, Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L, Afonyushkin T, Murphy JE, Fogelstrand P, Donzé O, Pasterkamp G, Hoke M, Kubicek S, Jørgensen HF, Danchin N, Simon T, Scharnagl H, März W, Borén J, Hess H, Mallat Z, Schneider P, Binder CJ. Tsiantoulas D, et al. Among authors: binder cj. Nature. 2021 Sep;597(7874):92-96. doi: 10.1038/s41586-021-03818-3. Epub 2021 Aug 25. Nature. 2021. PMID: 34433968
Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies.
Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. Tsiantoulas D, et al. Among authors: binder cj. J Lipid Res. 2015 Feb;56(2):440-8. doi: 10.1194/jlr.P054569. Epub 2014 Dec 18. J Lipid Res. 2015. PMID: 25525116 Free PMC article.
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