Mitchell DA - Search Results

1

A new genome-mining tool redefines the lasso peptide biosynthetic landscape.

Tietz JI, Schwalen CJ, Patel PS, Maxson T, Blair PM, Tai HC, Zakai UI, Mitchell DA. Tietz JI, et al. Among authors: mitchell da. Nat Chem Biol. 2017 May;13(5):470-478. doi: 10.1038/nchembio.2319. Epub 2017 Feb 28. Nat Chem Biol. 2017. PMID: 28244986 Free PMC article.

2

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates.

Melby JO, Nard NJ, Mitchell DA. Melby JO, et al. Among authors: mitchell da. Curr Opin Chem Biol. 2011 Jun;15(3):369-78. doi: 10.1016/j.cbpa.2011.02.027. Epub 2011 Mar 21. Curr Opin Chem Biol. 2011. PMID: 21429787 Free PMC article. Review.

3

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.

Dunbar KL, Melby JO, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. Nat Chem Biol. 2012 Apr 22;8(6):569-75. doi: 10.1038/nchembio.944. Nat Chem Biol. 2012. PMID: 22522320 Free PMC article.

4

Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.

Dunbar KL, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. ACS Chem Biol. 2013 Mar 15;8(3):473-87. doi: 10.1021/cb3005325. Epub 2013 Jan 8. ACS Chem Biol. 2013. PMID: 23286465 Free PMC article. Review.

5

Engineering unnatural variants of plantazolicin through codon reprogramming.

Deane CD, Melby JO, Molohon KJ, Susarrey AR, Mitchell DA. Deane CD, et al. Among authors: mitchell da. ACS Chem Biol. 2013 Sep 20;8(9):1998-2008. doi: 10.1021/cb4003392. Epub 2013 Jul 3. ACS Chem Biol. 2013. PMID: 23823732 Free PMC article.

6

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis.

Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA. Lee J, et al. Among authors: mitchell da. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12954-9. doi: 10.1073/pnas.1306101110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878226 Free PMC article.

7

Lessons learned from the transformation of natural product discovery to a genome-driven endeavor.

Deane CD, Mitchell DA. Deane CD, et al. Among authors: mitchell da. J Ind Microbiol Biotechnol. 2014 Feb;41(2):315-31. doi: 10.1007/s10295-013-1361-8. Epub 2013 Oct 19. J Ind Microbiol Biotechnol. 2014. PMID: 24142337 Free PMC article. Review.

8

Nucleophilic 1,4-additions for natural product discovery.

Cox CL, Tietz JI, Sokolowski K, Melby JO, Doroghazi JR, Mitchell DA. Cox CL, et al. Among authors: mitchell da. ACS Chem Biol. 2014 Sep 19;9(9):2014-22. doi: 10.1021/cb500324n. Epub 2014 Jun 17. ACS Chem Biol. 2014. PMID: 24937678 Free PMC article.

9

Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS.

Zhang Q, Ortega M, Shi Y, Wang H, Melby JO, Tang W, Mitchell DA, van der Donk WA. Zhang Q, et al. Among authors: mitchell da. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12031-6. doi: 10.1073/pnas.1406418111. Epub 2014 Aug 4. Proc Natl Acad Sci U S A. 2014. PMID: 25092299 Free PMC article.

10

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.

Dunbar KL, Chekan JR, Cox CL, Burkhart BJ, Nair SK, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. Nat Chem Biol. 2014 Oct;10(10):823-9. doi: 10.1038/nchembio.1608. Epub 2014 Aug 17. Nat Chem Biol. 2014. PMID: 25129028 Free PMC article.

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