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Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
MacPherson KP, Sompol P, Kannarkat GT, Chang J, Sniffen L, Wildner ME, Norris CM, Tansey MG. MacPherson KP, et al. Among authors: wildner me. Neurobiol Dis. 2017 Jun;102:81-95. doi: 10.1016/j.nbd.2017.02.010. Epub 2017 Feb 24. Neurobiol Dis. 2017. PMID: 28237313 Free PMC article.
Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595.
Eidson LN, deSousa Rodrigues ME, Johnson MA, Barnum CJ, Duke BJ, Yang Y, Chang J, Kelly SD, Wildner M, Tesi RJ, Tansey MG. Eidson LN, et al. Among authors: wildner m. Brain Behav Immun. 2019 Oct;81:305-316. doi: 10.1016/j.bbi.2019.06.027. Epub 2019 Jun 25. Brain Behav Immun. 2019. PMID: 31251975 Free PMC article.