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An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.
Bentley L, Esapa CT, Nesbit MA, Head RA, Evans H, Lath D, Scudamore CL, Hough TA, Podrini C, Hannan FM, Fraser WD, Croucher PI, Brown MA, Brown SD, Cox RD, Thakker RV. Bentley L, et al. Among authors: cox rd. Endocrinology. 2014 Mar;155(3):908-22. doi: 10.1210/en.2013-1247. Epub 2013 Dec 3. Endocrinology. 2014. PMID: 24302625 Free PMC article.
On the evolutionary origins of obesity: a new hypothesis.
Sellayah D, Cagampang FR, Cox RD. Sellayah D, et al. Among authors: cox rd. Endocrinology. 2014 May;155(5):1573-88. doi: 10.1210/en.2013-2103. Epub 2014 Feb 26. Endocrinology. 2014. PMID: 24605831 Review.
FTO influences adipogenesis by regulating mitotic clonal expansion.
Merkestein M, Laber S, McMurray F, Andrew D, Sachse G, Sanderson J, Li M, Usher S, Sellayah D, Ashcroft FM, Cox RD. Merkestein M, et al. Among authors: cox rd. Nat Commun. 2015 Apr 17;6:6792. doi: 10.1038/ncomms7792. Nat Commun. 2015. PMID: 25881961 Free PMC article.
The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).
Hannan FM, Walls GV, Babinsky VN, Nesbit MA, Kallay E, Hough TA, Fraser WD, Cox RD, Hu J, Spiegel AM, Thakker RV. Hannan FM, et al. Among authors: cox rd. Endocrinology. 2015 Sep;156(9):3114-21. doi: 10.1210/en.2015-1269. Epub 2015 Jun 8. Endocrinology. 2015. PMID: 26052899 Free PMC article.
Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.
Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, Cox RD, Richards D, Rorsman P, Thakker RV. Babinsky VN, et al. Among authors: cox rd. Endocrinology. 2017 Aug 1;158(8):2486-2502. doi: 10.1210/en.2017-00111. Endocrinology. 2017. PMID: 28575322 Free PMC article.
A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability.
Mušo M, Dumbell R, Pulit S, Sinnott-Armstrong N, Laber S, Zolkiewski L, Bentley L, Claussnitzer M, Cox RD. Mušo M, et al. Among authors: cox rd. Biochim Biophys Acta Gene Regul Mech. 2020 Nov;1863(11):194640. doi: 10.1016/j.bbagrm.2020.194640. Epub 2020 Sep 30. Biochim Biophys Acta Gene Regul Mech. 2020. PMID: 33007465 Free PMC article.
A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.
Sinnott-Armstrong N, Sousa IS, Laber S, Rendina-Ruedy E, Nitter Dankel SE, Ferreira T, Mellgren G, Karasik D, Rivas M, Pritchard J, Guntur AR, Cox RD, Lindgren CM, Hauner H, Sallari R, Rosen CJ, Hsu YH, Lander ES, Kiel DP, Claussnitzer M. Sinnott-Armstrong N, et al. Among authors: cox rd. Cell Metab. 2021 Mar 2;33(3):615-628.e13. doi: 10.1016/j.cmet.2021.01.001. Epub 2021 Jan 28. Cell Metab. 2021. PMID: 33513366 Free PMC article.
Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
Laber S, Forcisi S, Bentley L, Petzold J, Moritz F, Smirnov KS, Al Sadat L, Williamson I, Strobel S, Agnew T, Sengupta S, Nicol T, Grallert H, Heier M, Honecker J, Mianne J, Teboul L, Dumbell R, Long H, Simon M, Lindgren C, Bickmore WA, Hauner H, Schmitt-Kopplin P, Claussnitzer M, Cox RD. Laber S, et al. Among authors: cox rd. Sci Adv. 2021 Jul 21;7(30):eabg0108. doi: 10.1126/sciadv.abg0108. Print 2021 Jul. Sci Adv. 2021. PMID: 34290091 Free PMC article.
203 results