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Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.
Duvall JR, Bedard L, Naylor-Olsen AM, Manson AL, Bittker JA, Sun W, Fitzgerald ME, He Z, Lee MD 4th, Marie JC, Muncipinto G, Rush D, Xu D, Xu H, Zhang M, Earl AM, Palmer MA, Foley MA, Vacca JP, Scherer CA. Duvall JR, et al. Among authors: zhang m. ACS Infect Dis. 2017 May 12;3(5):349-359. doi: 10.1021/acsinfecdis.6b00206. Epub 2017 Mar 7. ACS Infect Dis. 2017. PMID: 28215073 Free PMC article.
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Vinayak S, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B, Huston CD, Comer E. Vinayak S, et al. Among authors: zhang m. Sci Transl Med. 2020 Sep 30;12(563):eaba8412. doi: 10.1126/scitranslmed.aba8412. Sci Transl Med. 2020. PMID: 32998973 Free PMC article.
Selective Inhibitors of G2019S-LRRK2 Kinase Activity.
Garofalo AW, Bright J, De Lombaert S, Toda AMA, Zobel K, Andreotti D, Beato C, Bernardi S, Budassi F, Caberlotto L, Gao P, Griffante C, Liu X, Mengatto L, Migliore M, Sabbatini FM, Sava A, Serra E, Vincetti P, Zhang M, Carlisle HJ. Garofalo AW, et al. Among authors: zhang m. J Med Chem. 2020 Dec 10;63(23):14821-14839. doi: 10.1021/acs.jmedchem.0c01243. Epub 2020 Nov 16. J Med Chem. 2020. PMID: 33197196
Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.
Garofalo AW, Schwarz J, Zobel K, Beato C, Bernardi S, Budassi F, Caberlotto L, Gao P, Griffante C, Liu X, Migliore M, Qiao F, Sabbatini FM, Sava A, Zhang M, Carlisle HJ. Garofalo AW, et al. Among authors: zhang m. Bioorg Med Chem Lett. 2023 Oct 15;95:129487. doi: 10.1016/j.bmcl.2023.129487. Epub 2023 Sep 19. Bioorg Med Chem Lett. 2023. PMID: 37734423
Protein-ligand interaction-guided discovery of novel VEGFR-2 inhibitors.
Zhang Y, Zhang M, Wang Y, Fan Y, Chen X, Yang Y, Hua Y, Xie W, Lu T, Tang W, Chen Y, Liu H. Zhang Y, et al. Among authors: zhang m. J Biomol Struct Dyn. 2020 Jun;38(9):2559-2574. doi: 10.1080/07391102.2019.1635915. Epub 2019 Jul 2. J Biomol Struct Dyn. 2020. PMID: 31232191
Role of complement factor D in cardiovascular and metabolic diseases.
Kong Y, Wang N, Tong Z, Wang D, Wang P, Yang Q, Yan X, Song W, Jin Z, Zhang M. Kong Y, et al. Among authors: zhang m. Front Immunol. 2024 Oct 2;15:1453030. doi: 10.3389/fimmu.2024.1453030. eCollection 2024. Front Immunol. 2024. PMID: 39416783 Free PMC article. Review.
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