Wei J - Search Results

1

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential.

Wei J, Yang Y, Li Y, Mo X, Guo X, Zhang X, Xu X, Jiang Z, You Q. Wei J, et al. Bioorg Med Chem. 2017 Mar 15;25(6):1737-1746. doi: 10.1016/j.bmc.2016.06.021. Epub 2016 Jun 11. Bioorg Med Chem. 2017. PMID: 28209257

2

Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.

Jia J, Xu X, Liu F, Guo X, Zhang M, Lu M, Xu L, Wei J, Zhu J, Zhang S, Zhang S, Sun H, You Q. Jia J, et al. Among authors: wei j. PLoS One. 2013;8(4):e59315. doi: 10.1371/journal.pone.0059315. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565147 Free PMC article.

3

Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors.

Xue X, Wei JL, Xu LL, Xi MY, Xu XL, Liu F, Guo XK, Wang L, Zhang XJ, Zhang MY, Lu MC, Sun HP, You QD. Xue X, et al. J Chem Inf Model. 2013 Oct 28;53(10):2715-29. doi: 10.1021/ci400348f. Epub 2013 Oct 7. J Chem Inf Model. 2013. PMID: 24050442

4

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Guo X, Ma X, Yang Q, Xu J, Huang L, Jia J, Shan J, Liu L, Chen W, Chu H, Wei J, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: wei j. Eur J Med Chem. 2014 Jun 23;81:89-94. doi: 10.1016/j.ejmech.2014.03.075. Epub 2014 Mar 28. Eur J Med Chem. 2014. PMID: 24824064

5

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: wei jl. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

6

Escape, or Vanish: Control the Fate of p53 through MDM2-Mediated Ubiquitination.

Wei J, Yang Y, Lu M, Xu L, Liu F, Yuan Z, Bao Q, Jiang Z, Xu X, Guo X, Zhang X, You Q, Sun H. Wei J, et al. Anticancer Agents Med Chem. 2015;16(2):174-89. doi: 10.2174/1871520615666150907093358. Anticancer Agents Med Chem. 2015. PMID: 26343143 Review.

7

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.

Xu XL, Bao QC, Jia JM, Liu F, Guo XK, Zhang MY, Wei JL, Lu MC, Xu LL, Zhang XJ, You QD, Sun HP. Xu XL, et al. Sci Rep. 2016 Jan 8;6:19004. doi: 10.1038/srep19004. Sci Rep. 2016. PMID: 26743233 Free PMC article.

8

Discovery and optimization of new benzofuran derivatives against p53-independent malignant cancer cells through inhibition of HIF-1 pathway.

Yang YR, Wei JL, Mo XF, Yuan ZW, Wang JL, Zhang C, Xie YY, You QD, Sun HP. Yang YR, et al. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2713-8. doi: 10.1016/j.bmcl.2016.03.112. Epub 2016 Apr 1. Bioorg Med Chem Lett. 2016. PMID: 27101893

9

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents.

Wei J, Yang Y, Lu M, Lei Y, Xu L, Jiang Z, Xu X, Guo X, Zhang X, Sun H, You Q. Wei J, et al. Mini Rev Med Chem. 2018;18(4):296-309. doi: 10.2174/1389557516666160630124938. Mini Rev Med Chem. 2018. PMID: 27484627 Review.

10

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway.

Xu XL, Yang YR, Mo XF, Wei JL, Zhang XJ, You QD. Xu XL, et al. Eur J Med Chem. 2017 Sep 8;137:45-62. doi: 10.1016/j.ejmech.2017.05.042. Epub 2017 May 22. Eur J Med Chem. 2017. PMID: 28554092

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