Horwitz SB - Search Results

1

Structural Basis of Microtubule Stabilization by Discodermolide.

Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB 3rd, Yang CH, McDaid HM, Paterson I, Horwitz SB, Fernando Díaz J, Steinmetz MO. Prota AE, et al. Among authors: horwitz sb. Chembiochem. 2017 May 18;18(10):905-909. doi: 10.1002/cbic.201600696. Epub 2017 Mar 27. Chembiochem. 2017. PMID: 28207984 Free PMC article.

2

Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent.

Chao SK, Lin J, Brouwer-Visser J, Smith AB 3rd, Horwitz SB, McDaid HM. Chao SK, et al. Among authors: horwitz sb. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):391-6. doi: 10.1073/pnas.1016962108. Epub 2010 Dec 20. Proc Natl Acad Sci U S A. 2011. PMID: 21173253 Free PMC article.

3

Taxol^®: The First Microtubule Stabilizing Agent.

Yang CH, Horwitz SB. Yang CH, et al. Among authors: horwitz sb. Int J Mol Sci. 2017 Aug 9;18(8):1733. doi: 10.3390/ijms18081733. Int J Mol Sci. 2017. PMID: 28792473 Free PMC article. Review.

4

Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, Steinmetz MO, Horwitz SB, Smith AB 3rd, McDaid HM. Guo B, et al. Among authors: horwitz sb. Mol Pharmacol. 2020 Aug;98(2):156-167. doi: 10.1124/mol.119.117457. Epub 2020 Jun 26. Mol Pharmacol. 2020. PMID: 32591477 Free PMC article.

5

Mechanisms of Taxol resistance related to microtubules.

Orr GA, Verdier-Pinard P, McDaid H, Horwitz SB. Orr GA, et al. Among authors: horwitz sb. Oncogene. 2003 Oct 20;22(47):7280-95. doi: 10.1038/sj.onc.1206934. Oncogene. 2003. PMID: 14576838 Free PMC article. Review.

6

The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence.

Klein LE, Freeze BS, Smith AB 3rd, Horwitz SB. Klein LE, et al. Among authors: horwitz sb. Cell Cycle. 2005 Mar;4(3):501-7. doi: 10.4161/cc.4.3.1550. Epub 2005 Mar 18. Cell Cycle. 2005. PMID: 15711127

7

Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice.

Huang GS, Lopez-Barcons L, Freeze BS, Smith AB 3rd, Goldberg GL, Horwitz SB, McDaid HM. Huang GS, et al. Among authors: horwitz sb. Clin Cancer Res. 2006 Jan 1;12(1):298-304. doi: 10.1158/1078-0432.CCR-05-0229. Clin Cancer Res. 2006. PMID: 16397055 Free PMC article.

8

A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.

Xia S, Kenesky CS, Rucker PV, Smith AB 3rd, Orr GA, Horwitz SB. Xia S, et al. Among authors: horwitz sb. Biochemistry. 2006 Oct 3;45(39):11762-75. doi: 10.1021/bi060497a. Biochemistry. 2006. PMID: 17002277

9

Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.

Khrapunovich-Baine M, Menon V, Verdier-Pinard P, Smith AB 3rd, Angeletti RH, Fiser A, Horwitz SB, Xiao H. Khrapunovich-Baine M, et al. Among authors: horwitz sb. Biochemistry. 2009 Dec 15;48(49):11664-77. doi: 10.1021/bi901351q. Biochemistry. 2009. PMID: 19863156 Free PMC article.

10

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence.

Chao SK, Horwitz SB, McDaid HM. Chao SK, et al. Among authors: horwitz sb. Oncotarget. 2011 Jan-Feb;2(1-2):89-98. doi: 10.18632/oncotarget.221. Oncotarget. 2011. PMID: 21399233 Free PMC article.

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