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Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Vikram A, et al. Among authors: kumar v, kumar s, kumar a. Nat Med. 2017 Mar;23(3):361-367. doi: 10.1038/nm.4284. Epub 2017 Feb 13. Nat Med. 2017. PMID: 28191886 Free PMC article.
Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.
Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman TA, Cole MP, Kumar A, Dericco JS, Jeon BH, Irani K. Jung SB, et al. Among authors: kumar a. Circ Res. 2010 Oct 1;107(7):877-87. doi: 10.1161/CIRCRESAHA.110.222968. Epub 2010 Aug 12. Circ Res. 2010. PMID: 20705923 Free PMC article.
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