Jacobs JS - Search Results

1

Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.

Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Vikram A, et al. Among authors: jacobs js. Nat Med. 2017 Mar;23(3):361-367. doi: 10.1038/nm.4284. Epub 2017 Feb 13. Nat Med. 2017. PMID: 28191886 Free PMC article.

2

Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1.

Vikram A, Kim YR, Kumar S, Li Q, Kassan M, Jacobs JS, Irani K. Vikram A, et al. Among authors: jacobs js. Nat Commun. 2016 Sep 2;7:12565. doi: 10.1038/ncomms12565. Nat Commun. 2016. PMID: 27586459 Free PMC article.

3

P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.

Li Q, Kim YR, Vikram A, Kumar S, Kassan M, Gabani M, Lee SK, Jacobs JS, Irani K. Li Q, et al. Among authors: jacobs js. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2394-2403. doi: 10.1161/ATVBAHA.116.308321. Epub 2016 Oct 27. Arterioscler Thromb Vasc Biol. 2016. PMID: 27789474 Free PMC article.

4

Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.

Kumar S, Kim YR, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid MM, Jacobs JS, Kumar A, Irani K. Kumar S, et al. Among authors: jacobs js. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1714-1719. doi: 10.1073/pnas.1614112114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137876 Free PMC article.

5

Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. Kassan M, et al. Among authors: jacobs js. Sci Rep. 2017 Feb 9;7:42265. doi: 10.1038/srep42265. Sci Rep. 2017. PMID: 28181559 Free PMC article.

6

Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. Kassan M, et al. Among authors: jacobs js. Sci Rep. 2017 Apr 10;7:46123. doi: 10.1038/srep46123. Sci Rep. 2017. PMID: 28394317 Free PMC article. No abstract available.

7

MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1.

Kassan M, Vikram A, Li Q, Kim YR, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. Kassan M, et al. Among authors: jacobs js. Sci Rep. 2017 Aug 24;7(1):9308. doi: 10.1038/s41598-017-06721-y. Sci Rep. 2017. PMID: 28839162 Free PMC article.

8

MiR-204 regulates type 1 IP₃R to control vascular smooth muscle cell contractility and blood pressure.

Gabani M, Liu J, Ait-Aissa K, Koval O, Kim YR, Castañeda D, Vikram A, Jacobs JS, Grumbach I, Trebak M, Irani K, Kassan M. Gabani M, et al. Among authors: jacobs js. Cell Calcium. 2019 Jun;80:18-24. doi: 10.1016/j.ceca.2019.03.006. Epub 2019 Mar 23. Cell Calcium. 2019. PMID: 30925290 Free PMC article.

9

SUMO2 regulates vascular endothelial function and oxidative stress in mice.

Kim YR, Jacobs JS, Li Q, Gaddam RR, Vikram A, Liu J, Kassan M, Irani K, Kumar S. Kim YR, et al. Among authors: jacobs js. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1292-H1300. doi: 10.1152/ajpheart.00530.2019. Epub 2019 Oct 4. Am J Physiol Heart Circ Physiol. 2019. PMID: 31584834 Free PMC article.

10

Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice.

Gaddam RR, Jacobsen VP, Kim YR, Gabani M, Jacobs JS, Dhuri K, Kumar S, Kassan M, Li Q, Bahal R, Roghair R, Irani K, Vikram A. Gaddam RR, et al. Among authors: jacobs js. Sci Rep. 2020 Jun 22;10(1):10065. doi: 10.1038/s41598-020-66786-0. Sci Rep. 2020. PMID: 32572127 Free PMC article.

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