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Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D. Chen Z, et al. Among authors: bellin m. Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. Eur Heart J. 2017. PMID: 28182242 Free PMC article.
Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.
Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. Moretti A, et al. Among authors: bellin m. FASEB J. 2010 Mar;24(3):700-11. doi: 10.1096/fj.09-139477. Epub 2009 Oct 22. FASEB J. 2010. PMID: 19850773
These results support the possibility to use patient-specific iPS-generated cardiovascular progenitors as a model to elucidate the pathogenesis of congenital and acquired forms of heart diseases.-Moretti, A., Bellin, M., Jung, C. B., Thies, T.-M., Takashima, …
These results support the possibility to use patient-specific iPS-generated cardiovascular progenitors as a model to elucidate the pathogene …
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL. Moretti A, et al. Among authors: bellin m. N Engl J Med. 2010 Oct 7;363(15):1397-409. doi: 10.1056/NEJMoa0908679. Epub 2010 Jul 21. N Engl J Med. 2010. PMID: 20660394 Free article.
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.
Jung CB, Moretti A, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P, Laugwitz KL. Jung CB, et al. Among authors: bellin m. EMBO Mol Med. 2012 Mar;4(3):180-91. doi: 10.1002/emmm.201100194. Epub 2012 Jan 25. EMBO Mol Med. 2012. PMID: 22174035 Free PMC article.
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.
Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz KL, Li M. Zhang H, et al. Among authors: bellin m. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. doi: 10.1073/pnas.1205266109. Epub 2012 Jun 28. Proc Natl Acad Sci U S A. 2012. PMID: 22745159 Free PMC article.
Induced pluripotent stem cells: the new patient?
Bellin M, Marchetto MC, Gage FH, Mummery CL. Bellin M, et al. Nat Rev Mol Cell Biol. 2012 Nov;13(11):713-26. doi: 10.1038/nrm3448. Epub 2012 Oct 4. Nat Rev Mol Cell Biol. 2012. PMID: 23034453 Review.
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M. Zhang M, et al. Among authors: bellin m. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92. doi: 10.1073/pnas.1419553111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453094 Free PMC article.
Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.
Ribeiro MC, Tertoolen LG, Guadix JA, Bellin M, Kosmidis G, D'Aniello C, Monshouwer-Kloots J, Goumans MJ, Wang YL, Feinberg AW, Mummery CL, Passier R. Ribeiro MC, et al. Among authors: bellin m. Biomaterials. 2015 May;51:138-150. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18. Biomaterials. 2015. PMID: 25771005
561 results