Lai Z - Search Results

1

The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata.

Huang Y, Liu X, Wu D, Tang G, Lai Z, Zheng X, Yin S, Luo HB. Huang Y, et al. Among authors: lai z. Biochem Pharmacol. 2017 Apr 15;130:51-59. doi: 10.1016/j.bcp.2017.01.016. Epub 2017 Jan 31. Biochem Pharmacol. 2017. PMID: 28159622

2

Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.

Yu YF, Zhang C, Huang YY, Zhang S, Zhou Q, Li X, Lai Z, Li Z, Gao Y, Wu Y, Guo L, Wu D, Luo HB. Yu YF, et al. Among authors: lai z. ACS Chem Neurosci. 2020 Apr 1;11(7):1058-1071. doi: 10.1021/acschemneuro.0c00024. Epub 2020 Mar 11. ACS Chem Neurosci. 2020. PMID: 32105440

3

Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension.

Wu D, Zhang T, Chen Y, Huang Y, Geng H, Yu Y, Zhang C, Lai Z, Wu Y, Guo X, Chen J, Luo HB. Wu D, et al. Among authors: lai z. J Med Chem. 2017 Aug 10;60(15):6622-6637. doi: 10.1021/acs.jmedchem.7b00523. Epub 2017 Jul 25. J Med Chem. 2017. PMID: 28686445

4

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease.

Zhang C, Zhou Q, Wu XN, Huang YD, Zhou J, Lai Z, Wu Y, Luo HB. Zhang C, et al. Among authors: lai z. J Enzyme Inhib Med Chem. 2018 Dec;33(1):260-270. doi: 10.1080/14756366.2017.1412315. J Enzyme Inhib Med Chem. 2018. PMID: 29271265 Free PMC article.

5

Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.

Zhang T, Lai Z, Yuan S, Huang YY, Dong G, Sheng C, Ke H, Luo HB. Zhang T, et al. Among authors: lai z. J Med Chem. 2020 Sep 10;63(17):9828-9837. doi: 10.1021/acs.jmedchem.0c00983. Epub 2020 Aug 27. J Med Chem. 2020. PMID: 32794708

6

One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides.

Li X, Wu S, Chen S, Lai Z, Luo HB, Sheng C. Li X, et al. Among authors: lai z. Org Lett. 2018 Apr 6;20(7):1712-1715. doi: 10.1021/acs.orglett.8b00016. Epub 2018 Mar 8. Org Lett. 2018. PMID: 29518327

7

Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin.

Lai ZW, Li C, Liu J, Kong L, Wen X, Sun H. Lai ZW, et al. Eur J Med Chem. 2014 Aug 18;83:547-60. doi: 10.1016/j.ejmech.2014.06.044. Epub 2014 Jun 23. Eur J Med Chem. 2014. PMID: 24996141

8

Total synthesis of (-)-8-deoxyserratinine via an efficient Helquist annulation and double N-alkylation reaction.

Yang YR, Lai ZW, Shen L, Huang JZ, Wu XD, Yin JL, Wei K. Yang YR, et al. Org Lett. 2010 Aug 6;12(15):3430-3. doi: 10.1021/ol1012444. Org Lett. 2010. PMID: 20586438

9

[Internal heat acupuncture therapy for 44 cases knee osteoarthritis of early to middle stages].

Lian J, Lai Z, Xu J, Lin R. Lian J, et al. Among authors: lai z. Zhongguo Zhen Jiu. 2025 Jan 12;45(1):27-30. doi: 10.13703/j.0255-2930.20240715-k0004. Zhongguo Zhen Jiu. 2025. PMID: 39777874 Clinical Trial. Chinese.

10

Application of targeted high-throughput sequencing as a diagnostic tool for neonatal genetic metabolic diseases following tandem mass spectrometry screening.

Lai G, Gu Q, Lai Z, Chen H, Tu X, Chen J, Huang J. Lai G, et al. Among authors: lai z. Front Public Health. 2024 Dec 24;12:1461141. doi: 10.3389/fpubh.2024.1461141. eCollection 2024. Front Public Health. 2024. PMID: 39776477 Free PMC article.

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