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A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients.
Rello J, Krenn CG, Locker G, Pilger E, Madl C, Balica L, Dugernier T, Laterre PF, Spapen H, Depuydt P, Vincent JL, Bogár L, Szabó Z, Völgyes B, Máñez R, Cakar N, Ramazanoglu A, Topeli A, Mastruzzo MA, Jasovich A, Remolif CG, Del Carmen Soria L, Andresen Hernandez MA, Ruiz Balart C, Krémer I, Molnár Z, von Sonnenburg F, Lyons A, Joannidis M, Burgmann H, Welte T, Klingler A, Hochreiter R, Westritschnig K. Rello J, et al. Among authors: spapen h. Crit Care. 2017 Feb 4;21(1):22. doi: 10.1186/s13054-017-1601-9. Crit Care. 2017. PMID: 28159015 Free PMC article. Clinical Trial.
Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients.
Russell JA, Vincent JL, Kjølbye AL, Olsson H, Blemings A, Spapen H, Carl P, Laterre PF, Grundemar L. Russell JA, et al. Among authors: spapen h. Crit Care. 2017 Aug 15;21(1):213. doi: 10.1186/s13054-017-1798-7. Crit Care. 2017. PMID: 28807037 Free PMC article. Clinical Trial.
Efficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients-a randomized clinical trial.
Adlbrecht C, Wurm R, Depuydt P, Spapen H, Lorente JA, Staudinger T, Creteur J, Zauner C, Meier-Hellmann A, Eller P, Laenen MV, Molnár Z, Várkonyi I, Schaaf B, Héjja M, Šrámek V, Schneider H, Kanesa-Thasan N, Eder-Lingelbach S, Klingler A, Dubischar K, Wressnigg N, Rello J. Adlbrecht C, et al. Among authors: spapen h. Crit Care. 2020 Mar 4;24(1):74. doi: 10.1186/s13054-020-2792-z. Crit Care. 2020. PMID: 32131866 Free PMC article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of once-weekly subcutaneous epoetin alfa in critically ill patients: results of a randomized, double-blind, placebo-controlled trial.
Vincent JL, Spapen HD, Creteur J, Piagnerelli M, Hubloue I, Diltoer M, Roman A, Stevens E, Vercammen E, Beaver JS. Vincent JL, et al. Among authors: spapen hd. Crit Care Med. 2006 Jun;34(6):1661-7. doi: 10.1097/01.CCM.0000217919.22155.85. Crit Care Med. 2006. PMID: 16607233 Clinical Trial.
Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?
Delattre IK, Taccone FS, Jacobs F, Hites M, Dugernier T, Spapen H, Laterre PF, Wallemacq PE, Van Bambeke F, Tulkens PM. Delattre IK, et al. Among authors: spapen h. Expert Rev Anti Infect Ther. 2017 Jul;15(7):677-688. doi: 10.1080/14787210.2017.1338139. Epub 2017 Jun 19. Expert Rev Anti Infect Ther. 2017. PMID: 28571493
271 results