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Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Micanovic R, Khan S, Janosevic D, Lee ME, Hato T, Srour EF, Winfree S, Ghosh J, Tong Y, Rice SE, Dagher PC, Wu XR, El-Achkar TM. Micanovic R, et al. Among authors: khan s. J Am Soc Nephrol. 2018 Mar;29(3):841-856. doi: 10.1681/ASN.2017040409. Epub 2017 Nov 27. J Am Soc Nephrol. 2018. PMID: 29180395 Free PMC article.
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.
LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, McClintick J, Witzmann FA, Winfree S, Phillips CL, Hato T, Dagher PC, Wu XR, El-Achkar TM, Micanovic R. LaFavers KA, et al. Among authors: khan s. Sci Transl Med. 2019 Oct 2;11(512):eaaw3639. doi: 10.1126/scitranslmed.aaw3639. Sci Transl Med. 2019. PMID: 31578243 Free PMC article.
VEGFR3 tyrosine kinase inhibition aggravates cisplatin nephrotoxicity.
Black LM, Farrell ER, Barwinska D, Osis G, Zmijewska AA, Traylor AM, Esman SK, Bolisetty S, Whipple G, Kamocka MM, Winfree S, Spangler DR, Khan S, Zarjou A, El-Achkar TM, Agarwal A. Black LM, et al. Among authors: khan s. Am J Physiol Renal Physiol. 2021 Dec 1;321(6):F675-F688. doi: 10.1152/ajprenal.00186.2021. Epub 2021 Oct 18. Am J Physiol Renal Physiol. 2021. PMID: 34658261 Free PMC article.
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain.
Micanovic R, LaFavers KA, Patidar KR, Ghabril MS, Doud EH, Mosley AL, Sabo AR, Khan S, El-Achkar TM. Micanovic R, et al. Among authors: khan s. Am J Physiol Renal Physiol. 2022 Apr 1;322(4):F403-F418. doi: 10.1152/ajprenal.00322.2021. Epub 2022 Jan 31. Am J Physiol Renal Physiol. 2022. PMID: 35100812 Free PMC article.
The kidney protects against sepsis by producing systemic uromodulin.
LaFavers KA, Hage CA, Gaur V, Micanovic R, Hato T, Khan S, Winfree S, Doshi S, Moorthi RN, Twigg H, Wu XR, Dagher PC, Srour EF, El-Achkar TM. LaFavers KA, et al. Among authors: khan s. Am J Physiol Renal Physiol. 2022 Aug 1;323(2):F212-F226. doi: 10.1152/ajprenal.00146.2022. Epub 2022 Jun 27. Am J Physiol Renal Physiol. 2022. PMID: 35759740 Free PMC article.
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