Shibata N - Search Results

1

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, Ujikawa O, Shimokawa K, Sano O, Koyama R, Fujita H, Teratani M, Matsumoto H, Imaeda Y, Nara H, Cho N, Naito M. Ohoka N, et al. Among authors: shibata n. J Biol Chem. 2017 Mar 17;292(11):4556-4570. doi: 10.1074/jbc.M116.768853. Epub 2017 Feb 2. J Biol Chem. 2017. PMID: 28154167 Free PMC article.

2

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami T, Okuda H, Kurihara M, Naito M. Okuhira K, et al. Among authors: shibata n. Cancer Sci. 2013 Nov;104(11):1492-8. doi: 10.1111/cas.12272. Epub 2013 Oct 11. Cancer Sci. 2013. PMID: 23992566 Free PMC article.

3

Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.

Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, Naito M. Ohoka N, et al. Among authors: shibata n. Cell Death Dis. 2014 Nov 6;5(11):e1513. doi: 10.1038/cddis.2014.471. Cell Death Dis. 2014. PMID: 25375378 Free PMC article.

4

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.

Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M. Shibata N, et al. J Biol Chem. 2015 Nov 20;290(47):28428-28437. doi: 10.1074/jbc.M115.670901. Epub 2015 Oct 6. J Biol Chem. 2015. PMID: 26442586 Free PMC article.

5

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.

Ohoka N, Shibata N, Hattori T, Naito M. Ohoka N, et al. Among authors: shibata n. Curr Cancer Drug Targets. 2016;16(2):136-46. doi: 10.2174/1568009616666151112122502. Curr Cancer Drug Targets. 2016. PMID: 26560118 Review.

6

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Kurihara M, Naito M. Okuhira K, et al. Among authors: shibata n. Methods Mol Biol. 2016;1366:549-560. doi: 10.1007/978-1-4939-3127-9_42. Methods Mol Biol. 2016. PMID: 26585163

7

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

Demizu Y, Shibata N, Hattori T, Ohoka N, Motoi H, Misawa T, Shoda T, Naito M, Kurihara M. Demizu Y, et al. Among authors: shibata n. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4865-4869. doi: 10.1016/j.bmcl.2016.09.041. Epub 2016 Sep 15. Bioorg Med Chem Lett. 2016. PMID: 27666635

8

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

Okuhira K, Shoda T, Omura R, Ohoka N, Hattori T, Shibata N, Demizu Y, Sugihara R, Ichino A, Kawahara H, Itoh Y, Ishikawa M, Hashimoto Y, Kurihara M, Itoh S, Saito H, Naito M. Okuhira K, et al. Among authors: shibata n. Mol Pharmacol. 2017 Mar;91(3):159-166. doi: 10.1124/mol.116.105569. Epub 2016 Dec 13. Mol Pharmacol. 2017. PMID: 27965304

9

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

Ohoka N, Nagai K, Shibata N, Hattori T, Nara H, Cho N, Naito M. Ohoka N, et al. Among authors: shibata n. Cancer Sci. 2017 May;108(5):1032-1041. doi: 10.1111/cas.13198. Epub 2017 Apr 26. Cancer Sci. 2017. PMID: 28192613 Free PMC article.

10

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

Shibata N, Miyamoto N, Nagai K, Shimokawa K, Sameshima T, Ohoka N, Hattori T, Imaeda Y, Nara H, Cho N, Naito M. Shibata N, et al. Cancer Sci. 2017 Aug;108(8):1657-1666. doi: 10.1111/cas.13284. Epub 2017 Jun 19. Cancer Sci. 2017. PMID: 28556300 Free PMC article.

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