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Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.
Widen JC, Kempema AM, Villalta PW, Harki DA. Widen JC, et al. Among authors: harki da. ACS Chem Biol. 2017 Jan 20;12(1):102-113. doi: 10.1021/acschembio.6b00751. Epub 2016 Nov 28. ACS Chem Biol. 2017. PMID: 28103680 Free PMC article.
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.
Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS. Li M, et al. Among authors: harki da. ACS Chem Biol. 2012 Mar 16;7(3):506-17. doi: 10.1021/cb200440y. Epub 2012 Jan 17. ACS Chem Biol. 2012. PMID: 22181350 Free PMC article.
Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.
Hexum JK, Tello-Aburto R, Struntz NB, Harned AM, Harki DA. Hexum JK, et al. Among authors: harki da. ACS Med Chem Lett. 2012 Jun 14;3(6):459-464. doi: 10.1021/ml300034a. Epub 2012 May 11. ACS Med Chem Lett. 2012. PMID: 22866208 Free PMC article.
A redox economical synthesis of bioactive 6,12-guaianolides.
Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM. Wen B, et al. Among authors: harki da. Org Lett. 2013 Jun 7;15(11):2644-7. doi: 10.1021/ol400904y. Epub 2013 May 10. Org Lett. 2013. PMID: 23662902 Free PMC article.
Parthenolide prodrug LC-1 slows growth of intracranial glioma.
Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA. Hexum JK, et al. Among authors: harki da. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2493-5. doi: 10.1016/j.bmcl.2015.04.058. Epub 2015 Apr 25. Bioorg Med Chem Lett. 2015. PMID: 25978958
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Kempema AM, et al. Among authors: harki da. Bioorg Med Chem. 2015 Aug 1;23(15):4737-4745. doi: 10.1016/j.bmc.2015.05.037. Epub 2015 May 30. Bioorg Med Chem. 2015. PMID: 26088334 Free PMC article.
76 results