Brekken RA - Search Results

1

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers.

Tagal V, Wei S, Zhang W, Brekken RA, Posner BA, Peyton M, Girard L, Hwang T, Wheeler DA, Minna JD, White MA, Gazdar AF, Roth MG. Tagal V, et al. Among authors: brekken ra. Nat Commun. 2017 Jan 19;8:14098. doi: 10.1038/ncomms14098. Nat Commun. 2017. PMID: 28102363 Free PMC article.

2

Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer.

Holloway SE, Beck AW, Girard L, Jaber MR, Barnett CC Jr, Brekken RA, Fleming JB. Holloway SE, et al. Among authors: brekken ra. J Am Coll Surg. 2005 Mar;200(3):371-7. doi: 10.1016/j.jamcollsurg.2004.10.005. J Am Coll Surg. 2005. PMID: 15737847

3

Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.

Castro-Rivera E, Ran S, Brekken RA, Minna JD. Castro-Rivera E, et al. Among authors: brekken ra. Cancer Res. 2008 Oct 15;68(20):8295-303. doi: 10.1158/0008-5472.CAN-07-6601. Cancer Res. 2008. PMID: 18922901 Free PMC article.

4

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.

Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF. Soh J, et al. PLoS One. 2009 Oct 14;4(10):e7464. doi: 10.1371/journal.pone.0007464. PLoS One. 2009. PMID: 19826477 Free PMC article.

5

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.

Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA. Dineen SP, et al. Among authors: brekken ra. Cancer Res. 2010 Apr 1;70(7):2852-61. doi: 10.1158/0008-5472.CAN-09-3892. Epub 2010 Mar 23. Cancer Res. 2010. PMID: 20332237 Free PMC article.

6

TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.

Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA. Ou YH, et al. Mol Cell. 2011 Feb 18;41(4):458-70. doi: 10.1016/j.molcel.2011.01.019. Mol Cell. 2011. PMID: 21329883 Free PMC article.

7

Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts.

Zhang YA, Maitra A, Hsieh JT, Rudin CM, Peacock CD, Karikari C, Brekken RA, Stastny V, Gao B, Girard L, Wistuba I, Frenkel E, Minna JD, Gazdar AF. Zhang YA, et al. Among authors: brekken ra. Cancer Biol Ther. 2011 Oct 1;12(7):617-28. doi: 10.4161/cbt.12.7.15955. Epub 2011 Oct 1. Cancer Biol Ther. 2011. PMID: 21750403 Free PMC article.

8

SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner.

Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD. Greer RM, et al. Among authors: brekken ra. Cancer Res. 2011 Dec 15;71(24):7640-8. doi: 10.1158/0008-5472.CAN-10-3947. Epub 2011 Nov 2. Cancer Res. 2011. PMID: 22049529 Free PMC article.

9

Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.

Gerber DE, Gupta P, Dellinger MT, Toombs JE, Peyton M, Duignan I, Malaby J, Bailey T, Burns C, Brekken RA, Loizos N. Gerber DE, et al. Among authors: brekken ra. Mol Cancer Ther. 2012 Nov;11(11):2473-82. doi: 10.1158/1535-7163.MCT-12-0431. Epub 2012 Aug 28. Mol Cancer Ther. 2012. PMID: 22933705 Free PMC article.

10

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED. Wang L, et al. Among authors: brekken ra. Nat Commun. 2013;4:2035. doi: 10.1038/ncomms3035. Nat Commun. 2013. PMID: 23792809 Free PMC article.

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