Spring DR - Search Results

1

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Xu W, et al. Among authors: spring dr. J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7. J Am Chem Soc. 2017. PMID: 28084734 Free PMC article.

2

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.

Zheng S, Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR. Zheng S, et al. Among authors: spring dr. Org Biomol Chem. 2012 Apr 7;10(13):2590-3. doi: 10.1039/c2ob25065a. Epub 2012 Feb 23. Org Biomol Chem. 2012. PMID: 22361895

3

Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.

Tan YS, Śledź P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB. Tan YS, et al. Among authors: spring dr. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10078-81. doi: 10.1002/anie.201205676. Epub 2012 Sep 7. Angew Chem Int Ed Engl. 2012. PMID: 22961729 Free PMC article. No abstract available.

4

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.

Beckmann HS, Nie F, Hagerman CE, Johansson H, Tan YS, Wilcke D, Spring DR. Beckmann HS, et al. Among authors: spring dr. Nat Chem. 2013 Oct;5(10):861-7. doi: 10.1038/nchem.1729. Epub 2013 Aug 25. Nat Chem. 2013. PMID: 24056343

5

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis.

Ibbeson BM, Laraia L, Alza E, O' Connor CJ, Tan YS, Davies HM, McKenzie G, Venkitaraman AR, Spring DR. Ibbeson BM, et al. Among authors: spring dr. Nat Commun. 2014;5:3155. doi: 10.1038/ncomms4155. Nat Commun. 2014. PMID: 24434687 Free article.

6

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

Lau YH, de Andrade P, Sköld N, McKenzie GJ, Venkitaraman AR, Verma C, Lane DP, Spring DR. Lau YH, et al. Among authors: spring dr. Org Biomol Chem. 2014 Jun 28;12(24):4074-7. doi: 10.1039/c4ob00742e. Org Biomol Chem. 2014. PMID: 24817343

7

The use of chlorobenzene as a probe molecule in molecular dynamics simulations.

Tan YS, Spring DR, Abell C, Verma C. Tan YS, et al. Among authors: spring dr. J Chem Inf Model. 2014 Jul 28;54(7):1821-7. doi: 10.1021/ci500215x. Epub 2014 Jun 18. J Chem Inf Model. 2014. PMID: 24910248

8

Peptide stapling techniques based on different macrocyclisation chemistries.

Lau YH, de Andrade P, Wu Y, Spring DR. Lau YH, et al. Among authors: spring dr. Chem Soc Rev. 2015 Jan 7;44(1):91-102. doi: 10.1039/c4cs00246f. Epub 2014 Sep 8. Chem Soc Rev. 2015. PMID: 25199043 Review.

9

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.

Lau YH, de Andrade P, McKenzie GJ, Venkitaraman AR, Spring DR. Lau YH, et al. Among authors: spring dr. Chembiochem. 2014 Dec 15;15(18):2680-3. doi: 10.1002/cbic.201402374. Epub 2014 Oct 29. Chembiochem. 2014. PMID: 25354189

10

A two-component 'double-click' approach to peptide stapling.

Lau YH, Wu Y, de Andrade P, Galloway WR, Spring DR. Lau YH, et al. Among authors: spring dr. Nat Protoc. 2015 Apr;10(4):585-94. doi: 10.1038/nprot.2015.033. Epub 2015 Mar 12. Nat Protoc. 2015. PMID: 25763835

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