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Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
Szibor M, Dhandapani PK, Dufour E, Holmström KM, Zhuang Y, Salwig I, Wittig I, Heidler J, Gizatullina Z, Gainutdinov T; German Mouse Clinic Consortium; Fuchs H, Gailus-Durner V, de Angelis MH, Nandania J, Velagapudi V, Wietelmann A, Rustin P, Gellerich FN, Jacobs HT, Braun T. Szibor M, et al. Among authors: wietelmann a. Dis Model Mech. 2017 Feb 1;10(2):163-171. doi: 10.1242/dmm.027839. Epub 2016 Dec 14. Dis Model Mech. 2017. PMID: 28067626 Free PMC article.
Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.
Kubin T, Pöling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lörchner H, Schimanski S, Szibor M, Warnecke H, Braun T. Kubin T, et al. Among authors: wietelmann a. Cell Stem Cell. 2011 Nov 4;9(5):420-32. doi: 10.1016/j.stem.2011.08.013. Cell Stem Cell. 2011. PMID: 22056139 Free article.
Myostatin induces interstitial fibrosis in the heart via TAK1 and p38.
Biesemann N, Mendler L, Kostin S, Wietelmann A, Borchardt T, Braun T. Biesemann N, et al. Among authors: wietelmann a. Cell Tissue Res. 2015 Sep;361(3):779-87. doi: 10.1007/s00441-015-2139-2. Epub 2015 Mar 1. Cell Tissue Res. 2015. PMID: 25725788
Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure.
Pöling J, Gajawada P, Richter M, Lörchner H, Polyakova V, Kostin S, Shin J, Boettger T, Walther T, Rees W, Wietelmann A, Warnecke H, Kubin T, Braun T. Pöling J, et al. Among authors: wietelmann a. Basic Res Cardiol. 2014 Jan;109(1):396. doi: 10.1007/s00395-013-0396-3. Epub 2013 Nov 29. Basic Res Cardiol. 2014. PMID: 24292852
Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction.
Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H. Hoffmann J, et al. Among authors: wietelmann a. PLoS One. 2014 Jun 3;9(6):e98456. doi: 10.1371/journal.pone.0098456. eCollection 2014. PLoS One. 2014. PMID: 24893162 Free PMC article.
47 results