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An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.
Arencibia JM, Fröhner W, Krupa M, Pastor-Flores D, Merker P, Oellerich T, Neimanis S, Schmithals C, Köberle V, Süß E, Zeuzem S, Stark H, Piiper A, Odadzic D, Schulze JO, Biondi RM. Arencibia JM, et al. Among authors: neimanis s. ACS Chem Biol. 2017 Feb 17;12(2):564-573. doi: 10.1021/acschembio.6b00827. Epub 2017 Jan 13. ACS Chem Biol. 2017. PMID: 28045490
Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound.
Zhang H, Neimanis S, Lopez-Garcia LA, Arencibia JM, Amon S, Stroba A, Zeuzem S, Proschak E, Stark H, Bauer AF, Busschots K, Jørgensen TJ, Engel M, Schulze JO, Biondi RM. Zhang H, et al. Among authors: neimanis s. Chem Biol. 2014 Jun 19;21(6):754-65. doi: 10.1016/j.chembiol.2014.04.007. Epub 2014 May 15. Chem Biol. 2014. PMID: 24836908
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Schulze JO, Saladino G, Busschots K, Neimanis S, Süß E, Odadzic D, Zeuzem S, Hindie V, Herbrand AK, Lisa MN, Alzari PM, Gervasio FL, Biondi RM. Schulze JO, et al. Among authors: neimanis s. Cell Chem Biol. 2016 Oct 20;23(10):1193-1205. doi: 10.1016/j.chembiol.2016.06.017. Epub 2016 Sep 29. Cell Chem Biol. 2016. PMID: 27693059 Free article.
Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).
Dettori R, Sonzogni S, Meyer L, Lopez-Garcia LA, Morrice NA, Zeuzem S, Engel M, Piiper A, Neimanis S, Frödin M, Biondi RM. Dettori R, et al. Among authors: neimanis s. J Biol Chem. 2009 Oct 30;284(44):30318-27. doi: 10.1074/jbc.M109.051151. Epub 2009 Sep 1. J Biol Chem. 2009. PMID: 19723632 Free PMC article.
InterAKTions with FKBPs--mutational and pharmacological exploration.
Fabian AK, März A, Neimanis S, Biondi RM, Kozany C, Hausch F. Fabian AK, et al. Among authors: neimanis s. PLoS One. 2013;8(2):e57508. doi: 10.1371/journal.pone.0057508. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23469007 Free PMC article.
Regulation of nuclear import and export of negative cofactor 2.
Kahle J, Piaia E, Neimanis S, Meisterernst M, Doenecke D. Kahle J, et al. Among authors: neimanis s. J Biol Chem. 2009 Apr 3;284(14):9382-93. doi: 10.1074/jbc.M805694200. Epub 2009 Feb 9. J Biol Chem. 2009. PMID: 19204005 Free PMC article.
33 results